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Natural products in therapy

Prospects, goals and means in modern research

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Abstract

A review is presented which shows the vegetable kingdom as an almost inexhaustible reservoir of potential drugs. Some historical aspects about the use of plants and their constituents in medicine are dealt with. A number of problems connected with the search for new prototype drugs of biological origin is reported as well as modern methods used in this promising research. Some examples are given concerning recent results of investigations of plants used in traditional and modern medicine in China. Special attention is paid to the present role of natural products in therapy: as biologically active compounds as such, as starting materials for (semi)synthetic drugs and, last but not least, as source of inspiration or as models for the synthesis of new drugs with better therapeutic, chemical or physical properties than the original compounds.

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References

  • Bernauer, K., F. Berlage, W. von Philipsborn, H. Schmid andP. Karrer (1958)Helv. Chim. Acta 41, 2293.

    Google Scholar 

  • Bhatnagar, S.S., andP.V. Divekar (1953)Indian J. Pharm. 15, 307; viaChem. Abstr. (1954)48, 8488b.

    Google Scholar 

  • Bognár, R., S. Makleit andT. Mile (1968)Magy. Kem. Folyoirat. 74, 526.

    Google Scholar 

  • Bovet, D., andF. Bovet-Nitti (1948)Experientia 4, 325.

    Google Scholar 

  • Cox.J.S.G., J.E. Beach, A.M.J.N. Blair, A.J. Clarke, J. King, T.B. Lee, D.E.E. Loveday, G.F. Moss, T.S.C. Orr, J.T. Ritchie andP. Sheard (1970) In:Advances in Drug Research (Harper, N.J., andA.B. Simmonds, Eds.). Academic Press, London-New York, 115.

    Google Scholar 

  • Drobot'ko, V.G., B.E.Aizenman and S.I.Zelepukha (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 135; viaChem. Abstr. (1959)53, 8229e.

  • Euler, H. Von, andH. Erdtman (1935)Justus Liebigs Ann. Chem. 520, 1.

    Google Scholar 

  • Euler, H. Von, H. Erdtman andH. Hellström (1936)Ber. Dtsch. Chem. Ges. 69B, 743.

    Google Scholar 

  • Farnsworth, N.R. (1966)J. Pharm. Sci. 55, 225.

    Google Scholar 

  • Fitzmaurice, C., and T.B.Lee (1969)Brit. Pat. 1144905.

  • Gábor, M. (1975)Abriss der Pharmakologie der Flavonoiden. Akadémiai Kiadó, Budapest.

    Google Scholar 

  • George, M., andK.M. Pandalai (1949)Indian J. Med. Res. 37, 169; viaChem. Abstr. (1950)44, 7493g.

    Google Scholar 

  • Gorlenko, M.V. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov,Leningr. Gos. Univ. Kiev, 57; viaChem. Abstr. (1959)53, 8228b.

  • Gottshall, R.Y., E.H. Lucas, A. Lickfeldt andJ.M. Roberts (1949)J. Clin. Invest. 28, 920.

    Google Scholar 

  • Gottshall, R.Y., J.C. Jennings, L.E. Weller, C.T. Redemann, E.H. Lucas andH.M. Sell (1950)Am. Rev. Tuberc. 62, 475.

    Google Scholar 

  • Gran, L. (1973)The uteroactive principles of ‘KalataKalata’ (Oldenlandia affinis DC)., Ph.D. thesis, Bergen, Norway.

    Google Scholar 

  • Grewe, R. (1946)Naturwissenschaften 33, 333.

    Google Scholar 

  • Herrmann, E.C. Jr. (1961)Progr. Med. Virol. 3, 158.

    Google Scholar 

  • Hewitt, R.I., W.S. Wallace, E.R. Gill andJ.H. Williams (1952)Am. J. Trop. Hyg. 1, 768.

    Google Scholar 

  • Ieven, M., J. Totté, D. Vandenberghe andA.J. Vlietinck (1978)Planta Med. 33, 284.

    Google Scholar 

  • Irwin, S. (1962)Science 136, 123.

    Google Scholar 

  • Jang, C.S., F.Y. Fu, K.C. Huang andC.Y. Wang (1948)Nature 161, 400.

    Google Scholar 

  • Joshi, C.G., andN.G. Magar (1953)Indian J. Pharm. 15, 312; viaChem. Abstr. (1954)48, 8488g.

    Google Scholar 

  • Kartashova, N.N. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 62; viaChem. Abstr. (1959)53, 8228c.

  • King, H. (1935)J. Chem. Soc. 1281.

  • Knoll, J., S. Fürst andK. Kelemen (1973)J. Pharm. Pharmacol. 25, 929.

    Google Scholar 

  • Knoll, J., S. Fürst andS. Makleit (1975)J. Pharm. Pharmacol. 27, 99.

    Google Scholar 

  • Kobo, B. (1981)Pharmazie 36, 799.

    Google Scholar 

  • Komarova, M.A. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 84; viaChem. Abstr. (1959)53, 8228f.

  • Löfgren, N. (1946)Arkiv Kemi Mineral. Geol. A 22, No. 18, 30 pp.

  • Löfgren, N., andB. Lundqvist (1946)Svensk Kem. Tidskr. 58, 206.

    Google Scholar 

  • Lucas, E.H., A. Lickfeldt, R.Y. Gottshall andJ.C. Jennings (1951)Bull. Torrey Botan. Club 78, 310; viaChem. Abstr. (1951)45, 10296g.

    Google Scholar 

  • Malone, M.H. (1981) In:Proc. 7th Symposium Farmacognosie 1980 (Violon, Chr., V. Maes andA. Vercruysse, Eds.). Uitg. Vrije Universiteit Brussel, Brussels, 3.

    Google Scholar 

  • Narasimha Rao, P.L., andP.A. Kurup (1953)Indian J. Pharm. 15, 315; viaChem. Abstr. (1954)48, 8489a.

    Google Scholar 

  • Narasimha Rao, P.L., S.C.L. Verma, T.R. Gupta, D.V. Krishnamurti andT.B. Subba Rao (1953)Indian J. Pharm. 15, 316; viaChem. Abstr. (1954)48, 8489c.

    Google Scholar 

  • Noble, R.L. (1964)Proc. Intern. Pharmacol. Meeting, 2nd, Prague 1963, 63.

  • Okazaki, K., andS. Oshima (1952)J. Pharm. Soc. Japan 72, 558; viaChem. Abstr. (1952)46, 8811b.

    Google Scholar 

  • Okazaki, K., H. Kato andT. Wakatabe (1951)J. Pharm. Soc. Japan 71, 1–9 and 89–112; viaChem. Abstr. (1951)45, 5365i and 6689a.

    Google Scholar 

  • Osborn, E.M. (1943)Brit. J. Exptl. Pathol. 24, 227.

    Google Scholar 

  • Sandberg, F. (1973)Nobel 25, Chemistry in botanical classification, 303.

  • Sarett, L.H. (1946)J. Biol. Chem. 162, 601.

    Google Scholar 

  • Schönberg, A., andA. Sina (1950)J. Am. Chem. Soc. 72, 3396.

    Google Scholar 

  • Strauch, R., andK. Hiller (1974)Pharmazie 29, 656.

    Google Scholar 

  • Tang, W., andTh. Beyrich (1961)Pharmazie 16, 482.

    Google Scholar 

  • Tokin, B.P. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 5; viaChem. Abstr. (1959)53, 8227g.

  • Vandenberghe, D.A., M. Ieven, F. Mertens andA.J. Vlietinck (1978)Lloydia 41, 463.

    Google Scholar 

  • Venkatesh, D.S., B. Bheemeswar andM. Sreenivasaya (1953)Indian J. Pharm. 15, 305; viaChem. Abstr. (1954)48, 8488a.

    Google Scholar 

  • Woo, Lin-K. (1959)Seoul Univ. J. 8, 322.

    Google Scholar 

  • Yakimov, P.A. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov,Leningr. Gos. Univ. Kiev, 132; viaChem. Abstr. (1954)53, 8229é.

  • Yang, H.C., H.H. Chang andT.C. Weng (1953)J. Formosan Med. Assoc. 52, 109; viaChem. Abstr. (1953)47, 8175b.

    Google Scholar 

  • Xiao Peigen (1981) In:Natural Products as Medicinal Agents (Beal, J.L., andE. Reinhard, Eds.). Hippocrates Verlag, Stuttgart, 351.

    Google Scholar 

Download references

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Svendsen, A.B., Scheffer, J.J.C. Natural products in therapy. Pharmaceutisch Weekblad Scientific Edition 4, 93–103 (1982). https://doi.org/10.1007/BF01962629

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