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3,4-Disubstituted phenyliminoimidazolidines as potential prodrugs of the purported dopamine agonist 3,4-dihydroxyphenylimino-2-imidazolidine (DPI)

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Abstract

Aseries of ether derivatives of the purported dopamine agonist 3,4-dihydroxyphenylimino-2-imidazolidine (Dpi) has been prepared as potential prodrugs of the parent compound due to its relatively poor penetration into the brain. Their effects on both dopamine and noradrenaline utilization in the rat brain have been investigated using the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine. Apart from the parent compound,Dpi, the diphenylmethane ether analogue showed some dopaminergic activity.

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Authors and Affiliations

  1. Department of Pharmacy, University of Groningen, Antonius Deusinglaan 2, 9713, AW Groningen, The Netherlands

    H. A. Houwing, J. C. van Oene & A. S. Horn

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  1. H. A. Houwing
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  2. J. C. van Oene
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  3. A. S. Horn
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In honour of Professor Faber on the occasion of his 25-years' professorate.

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Houwing, H.A., van Oene, J.C. & Horn, A.S. 3,4-Disubstituted phenyliminoimidazolidines as potential prodrugs of the purported dopamine agonist 3,4-dihydroxyphenylimino-2-imidazolidine (DPI). Pharmaceutisch Weekblad Scientific Edition 5, 177–181 (1983). https://doi.org/10.1007/BF01961477

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  • DOI: https://doi.org/10.1007/BF01961477

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