Abstract
Doxorubicin and epirubicin solutions in plastic minibags for intravesical use were stored at −20° C and thawed at room temperature or by microwave radiation. Concentrations were measured with HPLC and TLC. Doxorubicin and epirubicin solutions could be frozen and stored at −20° C during at least two and four weeks, respectively, and subsequently thawed without loss of content. When the thawed doxorubicin solutions were refrozen and thawed again five weeks later, only a slight decrease of content was measured.
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Keusters, L., Stolk, L.M.L., Umans, R. et al. Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at −20° C and thawing by microwave radiation. Pharmaceutisch Weekblad Scientific Edition 8, 194–197 (1986). https://doi.org/10.1007/BF01959778
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DOI: https://doi.org/10.1007/BF01959778