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The beta-adrenoceptor-adenylate cyclase complex

From model to biochemical reality

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Abstract

Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.

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Authors and Affiliations

  1. Division of Medicinal Chemistry, Center for Bio-Pharmaceutical Sciences, P.O. Box 9502, 2300, RA Leiden, The Netherlands

    Ad P. Ijzerman

  2. Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV Amsterdam, The Netherlands

    Henk Timmerman

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  1. Ad P. Ijzerman
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Ijzerman, A.P., Timmerman, H. The beta-adrenoceptor-adenylate cyclase complex. Pharmaceutisch Weekblad Scientific Edition 8, 209–222 (1986). https://doi.org/10.1007/BF01957781

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