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Comparative bioavailability of rectal and oral formulations of chloroquine

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Abstract

The relative bioavailability of chloroquinone in Witepsol® H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.

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Authors and Affiliations

  1. Clinical Pharmacy Department, St. Elisabeth Hospital, Ringweg Kandenbroek 110, 2816, CP Amersfoort, The Netherlands

    Mathieu M. Tjoeng, Harry Kapelle & Marcel L. J. De Ridder

  2. St. Elisabeth Hospital, Amersfoort

    Paul H. G. Hogeman

  3. Internal Medicine Department, St. Elisabeth Hospital, Amersfoort

    H. Verhaar

Authors
  1. Mathieu M. Tjoeng
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  2. Paul H. G. Hogeman
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  3. Harry Kapelle
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  4. Marcel L. J. De Ridder
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  5. H. Verhaar
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Tjoeng, M.M., Hogeman, P.H.G., Kapelle, H. et al. Comparative bioavailability of rectal and oral formulations of chloroquine. Pharmaceutisch Weekblad Scientific Edition 13, 176–178 (1991). https://doi.org/10.1007/BF01957742

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  • DOI: https://doi.org/10.1007/BF01957742

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