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Relations between tablet properties

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Abstract

With the aid of simple mathematical models the relations between specific crushing strength (i.e. crushing strength divided by the breaking surface), friability and disintegration time of a tablet can be given. The friability is related to the porosity of the tablets and the specific crushing strength, independent of the process conditions. For the disintegration time two models have been used, depending on the disintegration mechanism. In the first one the disintegration time is only dependent on the porosity, in the second on the specific surface by weight of the granules of which the tablets are made. The theoretical relationships were verified for two tablet formulations, made under varying process conditions.

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Authors and Affiliations

  1. Akzo Corporate Research Department, P.O. Box 60, 6800, AB Arnhem, The Netherlands

    J. A. H. de Jong

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  1. J. A. H. de Jong
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de Jong, J.A.H. Relations between tablet properties. Pharmaceutisch Weekblad Scientific Edition 9, 24–28 (1987). https://doi.org/10.1007/BF01956488

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  • DOI: https://doi.org/10.1007/BF01956488

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