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A new and improved gas Chromatographic method for the determination of fluoride in plasma and faeces

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Abstract

A method is described that extracts fluoride selectively as trimethylfluorosilane using carbon tetrachloride and trimethylchlorosilane. Drawbacks of other methods as well as advantages of the proposed method are discussed.

The method is directly applicable to plasma and faeces samples, has a short gas Chromatographic run time due to the use of a backflush technique and is suitable for automation. Its lowest quantifiable limit for plasma and faeces is 10 μg/l and 1 μg/g fluoride respectively, using 1.0 ml or 1.0 g samples. Preliminary pharmacokinetic parameters of fluoride obtained in two subjects are reported.

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Authors and Affiliations

  1. Department of Hospital Pharmacy, State University Hospital Utrecht, Catharijnesingel 101, 3511, GV Utrecht, The Netherlands

    J. H. Glerum, A. van Dijk & S. W. Klein

  2. Department of Biopharmaceutics, Biopharmaceutical Laboratory, State University of Utrecht, Catharijnesingel 60, 3511, GV Utrecht, The Netherlands

    J. H. Glerum

Authors
  1. J. H. Glerum
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  2. A. van Dijk
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  3. S. W. Klein
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Glerum, J.H., van Dijk, A. & Klein, S.W. A new and improved gas Chromatographic method for the determination of fluoride in plasma and faeces. Pharmaceutisch Weekblad Scientific Edition 6, 75–79 (1984). https://doi.org/10.1007/BF01953958

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  • DOI: https://doi.org/10.1007/BF01953958

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