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Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration

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Abstract

Articainic acid, a major metabolite of articaine, was administered to a volunteer. Since the renewed interest in the utilization of articaine in epidural anaesthesia, it has been important to assess the clinical effects of this metabolite. It was noted that articainic acid had no effect on EEG, ECG, blood pressure and heart rate. Pharmacokinetic parameters are given.

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References

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Authors and Affiliations

  1. Department of Anaesthesiology, Hervormd Diaconessenhuis, Van Lawick van Pabststraat 72, 6814, HK Arnhem, the Netherlands

    G. E. C. J. M. van Oss

  2. Department of Clinical Pharmacy, Sint Radboud Hospital, P.O. Box 9101, 6500, HB Nijmegen, the Netherlands

    T. B. Vree, A. M. Baars & E. F. S. Termond

  3. Department of Anaesthesiology, Sint Radboud Hospital, Nijmegen

    T. B. Vree

  4. Department of Anaesthesiology, Free University Hospital, De Boelelaan 1117, 1081, HV Amsterdam, the Netherlands

    L. H. D. J. Booij

Authors
  1. G. E. C. J. M. van Oss
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  2. T. B. Vree
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  3. A. M. Baars
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  4. E. F. S. Termond
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  5. L. H. D. J. Booij
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van Oss, G.E.C.J.M., Vree, T.B., Baars, A.M. et al. Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration. Pharmaceutisch Weekblad Scientific Edition 10, 284–286 (1988). https://doi.org/10.1007/BF02219670

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  • DOI: https://doi.org/10.1007/BF02219670

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