Skip to main content

Anämie in der Schwangerschaft

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Die Geburtshilfe

Part of the book series: Springer Reference Medizin ((SRM))

  • 45 Accesses

Zusammenfassung

Anämien gehören zu den häufigsten Risikofaktoren in der Geburtshilfe und Perinatalmedizin. Die meisten internationalen Leitlinien empfehlen die zusätzliche Einnahme von 15–30 mg/Tag Eisen, um den im Verlauf der Schwangerschaft zunehmenden Eisenbedarf zu kompensieren.

Voraussetzung für die Abklärung einer Schwangerschaftsanämie ist die Festlegung des richtigen Cut-off-Werts für einen zu niedrigen Hämoglobin(Hb)-Wert in Abhängigkeit des Gestationsalters; ein Hb-Wert <10,5 g/dl kann zu jedem Zeitpunkt der Schwangerschaft als diagnostischer Hinweis für eine Anämie gewertet werden und bedarf der Abklärung. Weiteres wichtiges Diagnostikum ist die Bestimmung des Ferritinwerts. Die Therapie richtet sich nach der Ursache und Schwere der Anämie. Auch leichtere Formen müssen konsequent behandelt werden, um einer Aggravation und peripartalen Komplikationen bei hohen Blutverlusten vorzubeugen.

  • Eisenmangel in der Schwangerschaft ist häufig und kann mittels Screening des Serumferritins im 1. Trimester diagnostiziert werden (Grenzwert <30 μg/l). Regelmäßige Hb-Kontrollen zumindest 1-mal pro Trimester sind generell empfohlen.

  • Bei Eisenmangel mit oder ohne Anämie sollte in der Schwangerschaft primär eine Therapie mit oralen Eisenpräparaten erfolgen. Bei schwerer Eisenmangelanämie, Unverträglichkeit von oralem Eisen, fehlendem Ansprechen auf orales Eisen oder bei klinischer Notwendigkeit der raschen und effizienten Anämiekorrektur sollte eine intravenöse Eisentherapie durchgeführt werden.

  • Postparatal sollte bei leichter Eisenmangelanämie (Blutungsanämie) eine Therapie mit oralem Eisen und bei mittelschwerer bis schwerer Anämie (Hb <95 g/l) eine intravenöse Eisentherapie erfolgen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Literatur

  • ACOG Practice Bulletin No. 78 (2007) Hemoglobinopathies in pregnancy. Obstet Gynecol 109(1):229–237

    Article  Google Scholar 

  • Auerbach M, Pappadakis J, Bahrain H, Auerbach A, Ballard H, Dahl N (2011) Safety and efficacy of rapidly administered one gram of low molecular weight iron dextran (INFeD) for the treatment of iron deficient anemia. Am J Hematol 86(10):860–862

    Article  CAS  PubMed  Google Scholar 

  • Ayub R, Tariq N, Adil M, Iqbal M, Junaid A, Jaferry T (2008) Efficacy and safety of total dose infusion low molecular weight dextran in the treatment of iron deficiency anemia during pregnancy. J Coll Physicians Surg Pak 18:424–427

    PubMed  Google Scholar 

  • Baker R, Greer F (2010) Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0–3 years of age). Pediatrics 126:1040–1050

    Article  PubMed  Google Scholar 

  • Beguin Y, Lipcsei G, Thoumsin H, Fillet G (1991) Blunted erythropoietin production and decreased erythropoiesis in early pregnancy. Blood 78:89–91

    Article  CAS  PubMed  Google Scholar 

  • Bencaiova G, Krafft A, Burkhardt T, Breymann C (2006) Variable efficacy of recombinant human erythropoietin in anemic pregnant women with different forms of heterozygous hemoglobinopathy. Acta Haematol 116(4):259–265

    Article  CAS  PubMed  Google Scholar 

  • Bencaiova G, Burkhardt T, Breymann C (2012) Anemia, prevalence and risk factors in pregnancy. Eur J Intern Med 23:529–533

    Article  PubMed  Google Scholar 

  • Braga J, Marques R, Branco A, Jorge C (1996) Maternal and perinatal implications of the use of human recombinant erythropoietin. Acta Obstet Gynecol Scand 75:449–453

    Article  CAS  PubMed  Google Scholar 

  • Breymann C, Huch R (2008) Anemia in pregnancy and the puerperium, 3. Aufl. UNI-MED Science, Bremen. ISBN 978-3-8374-1022–1228

    Google Scholar 

  • Breymann C, Major A, Huch R, Huch A (1995) Recombinant human EPO and parenteral iron in the treatment of pregnancy anemia: a pilot study. Feto Maternal Hematology Research Group University of Zurich, Zurich, Switzerland. J Perinat Med 23:89–98

    Article  CAS  PubMed  Google Scholar 

  • Breymann C, Zimmermann R, Huch R, Huch A (1996) Use of recombinant erythropoietin in combination with parenteral iron in the treatment of postpartum anaemia. Eur J Clin Invest 26:123–130

    Article  CAS  PubMed  Google Scholar 

  • Breymann C, Visca E, Huch R, Huch A (2001) Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency anemia during pregnancy. Am J Obstet Gynecol 184:662–667

    Article  CAS  PubMed  Google Scholar 

  • Breymann C, Milman N, Mezzacasa A, Bernard R, Dudenhausen J, on behalf of the FER-ASAP investigators (2017) Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP). J Perinat Med 45(4):443–453. https://doi.org/10.1515/jpm-2016-0050

  • Bridges K (1990) Iron imbalance during pregnancy. In: Bern M, Frigoletto F (Hrsg) Hematologic disorders in maternal-fetal medicine. Wiley & Liss, New York, S 113–128

    Google Scholar 

  • Centers of Disease Control (CDC) (1989) CDC Criteria for anemia in children and childbearing-aged women. Morb Mortal Wkly Rep 38:400–404

    Google Scholar 

  • Charache S (1990) Hemoglobinopathies. In: Bern M, Frigoletto F (Hrsg) Hematologic disorders in maternal-fetal medicine. Wiley & Liss, New York, S 171–181

    Google Scholar 

  • Christoph P, Schuller C, Studer H, Irion O, Tejada BD, Surbek D (2012) Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. Iron sucrose. J Perinat Med 13:469–474

    Article  Google Scholar 

  • Cook J, Finch C, Smith N (1976) Evaluation of the iron status of a population. Blood 48:449–455

    Article  CAS  PubMed  Google Scholar 

  • Ekeroma A, Ansari A, Stirrat G (1997) Blood transfusion in obstetrics and gynaecology. Br J Obstet Gynaecol 104:278–284

    Article  CAS  PubMed  Google Scholar 

  • Fuchs D, Zangerle R, Dworzak E et al (1993) Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection. Eur J Haematol 50:90–94

    Article  CAS  PubMed  Google Scholar 

  • Gibson R (1990a) Assessment of iron status. In: Gibson R (Hrsg) Principles of nutritional assessment. Oxford University Press, New York, S 349–376

    Google Scholar 

  • Gibson R (1990b) Assessment of the status of folate and vitamin B-12. In: Gibson R (Hrsg) Principles of nutritional assessment. Oxford University Press, New York, S 461–486

    Google Scholar 

  • Hallberg L (1994) Prevention of iron deficiency. Baillieres Clin Haematol 7(4):805–814

    Article  CAS  PubMed  Google Scholar 

  • Harris E (1992) New insights into placental iron transport. Nutr Rev 50:329–331

    CAS  PubMed  Google Scholar 

  • Hercberg S, Preziosi P, Galan P (2001) Iron deficiency in Europe. Public Health Nutr 55:91–101

    Google Scholar 

  • Hollan S, Johansen K (1993) Adequate iron stores and the „nil nocere“ principle. Haematologia 25:69–84

    CAS  PubMed  Google Scholar 

  • Huch R, Huch A (1994) Erythropoietin in obstetrics. Hematol Oncol Clin North Am 8:1021–1040

    Article  CAS  PubMed  Google Scholar 

  • Kaufer M, Casanueva E (1990) Relation of pregnancy serum ferritin levels to hemoglobin levels throughout pregnancy. Eur J Clin Nutr 44:709–715

    CAS  PubMed  Google Scholar 

  • Khalafallah A, Dennis A, Ogden K (2012) Three-year follow up of a randomised clinical trial of intravenous versus oral iron for anaemia in pregnancy. BMJ Open 2(5):e000998

    Article  PubMed  PubMed Central  Google Scholar 

  • Krafft A, Perewusnyk G, Hänseler E, Quack K, Breymann C (2004b) The effect of postpartum oral iron supplementation on haematologic parameters in iron deficient women without anaemia. BJOG 111:1–6

    Google Scholar 

  • Krafft A, Bencaiova B, Breymann C (2009) Selective use of recombinant human erythropoietin in pregnant patients with severe anemia or nonresponsive to iron sucrose alone. Fetal Diagn Ther 25:239–245

    Article  PubMed  Google Scholar 

  • Krapels I, van Rooij I, Ocké M, West C, van der Horts C, Steegers-Theunissen R (2004) maternal nutritional status and the risk for orofacial cleft offspring in humans. J Nutr 134:3106–3113

    Article  CAS  PubMed  Google Scholar 

  • Krawinkel M, Bethge M, Karib AO, Ahmet HM, Mirghani OA (1990) Maternal ferritin values and fetal iron stores. Acta Paediatr Scand 79(4):467

    Article  CAS  PubMed  Google Scholar 

  • Malek A (2009) In vitro studies of ferric carboxymaltose on placental permeability using the dual perfusion model of human placenta. Drug Res 60(6a):354–361

    Google Scholar 

  • Mayhew TM, Charnock-Jones DS, Kaufmann P (2004) Aspects of human fetoplacental angiogenesis. Changes in complicated pregnancies. Placenta 25:127–139

    Article  CAS  PubMed  Google Scholar 

  • McCalla C (1994) Sickle cell disease in pregnacy. Postgrad Obstet Gynecol 14:1–5

    Google Scholar 

  • Milman N (2012) Oral iron prophylaxis in pregnancy – not too little and not too much. J Perinatol. https://doi.org/10.1155/2012/514345. (epub)

  • Milman N, Agger A, Nielsen O (1994) Iron status markers and serum erythropoietin in 120 mothers and newborn infants; effect of iron supplementation in normal pregnancy. Acta Obstet Gynecol Scand 73:200–204

    Article  CAS  PubMed  Google Scholar 

  • Mitchell E, Robinson E, Clark P, Becroft D, Glavisch N, Pattison N, Pryor J, Thompson J, Wild C (2004) Maternal nutritional risk factors for small gestational age babies in a developed country: a case control study. Arch Dis Child Fetal Neonatal Ed 89:F431–F435

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murray-Kolb L (2012) Maternal mortality, child mortality, perinatal mortality, child cognition and estimates of prevalence of anemia due to iron deficiency. The CHERG report 2012

    Google Scholar 

  • Neilson JP (2012) Biochemical tests of placental function for assessment in pregnancy. Cochrane Database Syst Rev (8). Art No: CD000108. https://doi.org/10.1002/14651858.CD000108.pub2

  • Pfenniger A, Schuller C, Christoph P, Surbek D (2012) Safety and efficacy of high-dose intravenous iron carboxymaltose vs. iron sucrose for treatment of postpartum anemia. J Perinat Med 40(4):397–402. https://doi.org/10.1515/jpm-2011-0239. PMID: 22752771

  • Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89:1052–1057

    Article  CAS  PubMed  Google Scholar 

  • Rehu M, Punnonen K, Ostland V, Heinonen S, Westerman M, Pulkki K, Sankilampi U (2010) Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol 85:345–352

    Article  CAS  PubMed  Google Scholar 

  • Reveiz L, Gyte GML, Cuervo LG, Casasbuenas A (2011) Treatments for iron-deficiency anaemia in pregnancy. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003094

  • Schaefer R, Schaefer L (1995) The hypochromic red cell: a new parameter for monitoring of iron supplementation during rhEPO therapy. J Perinat Med 23:83–88

    Article  CAS  PubMed  Google Scholar 

  • Spivak J (1995) Serum immunoreactive erythropoietin in health and disease. J Perinat Med 23:13–17

    Article  CAS  PubMed  Google Scholar 

  • USPSTF, US Preventive Services Task Force (1993) Routine iron supplementation during pregnancy. JAMA 15:2846–2854

    Google Scholar 

  • Van Santen S, Kroot J, Zijderveld G, Wiegerinck E, Spaanderman M, Swinkels D (2013) The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study. Clin Chem Lab Med 51:1395–1401

    PubMed  Google Scholar 

  • Warth J (1990) Sickle cell disease. In: Bern M, Frigoletto F (Hrsg) Hematologic disorders in maternal-fetal medicine. Wiley & Liss, New York, S 183–197

    Google Scholar 

  • Wesström J (2020) Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy. Arch Gynecol Obstet 301(5):1127–1131. https://doi.org/10.1007/s00404-020-05509-2. Epub 2020 Apr 8. PMID: 32270330; PMCID: PMC7181549

  • WHO World Health Organization (Hrsg) (2012) Global Burden of maternal anemia and iron deficiency. Englisch. Portugiesisch, Spanisch. ISBN: 978 92 4 150199 6

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christian Breymann .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Breymann, C. (2023). Anämie in der Schwangerschaft. In: von Kaisenberg, C., Klaritsch, P., Hösli-Krais, I. (eds) Die Geburtshilfe. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44369-9_23-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-44369-9_23-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-44369-9

  • Online ISBN: 978-3-662-44369-9

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Anämie in der Schwangerschaft
    Published:
    09 December 2023

    DOI: https://doi.org/10.1007/978-3-662-44369-9_23-2

  2. Original

    Anämie in der Schwangerschaft
    Published:
    17 July 2015

    DOI: https://doi.org/10.1007/978-3-662-44369-9_23-1