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Bioprinting and Biofabrication of Organs

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Handbook of Materials Structures, Properties, Processing and Performance
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Abstract

Using living cells in place of nanoparticles of other materials in an ink matrix, it is conceptually possible to print 3D organs. Using ink jet arrays controlled by CAD software, vascular cells can introduce appropriate vascularization or cylindrical vessels to allow blood flow. The successful integration of these functions into tissue engineering can allow for human organ printing. This chapter describes contemporary innovations in tissue engineering and 3D organ printing.

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References

  • Bausch AR, Kroy K (2006) A bottom-up approach to cell mechanics. Nat Phys 2:231–238

    Article  Google Scholar 

  • Bello Y, Falabella A, Eaglstein W (2001) Tissue-engineered skin. Current status in wound healing. Am J Clin Dermatol 2(5):305–313

    Article  Google Scholar 

  • Boland T, Xu T, Damon B, Cui X (2006) Application of inkjet printing to tissue engineering. Biotechnology 1:910–917

    Google Scholar 

  • Bottcher-Haberzeth S, Biedermann T, Reichmann E (2010) Tissue engineering of skin. Burns 36:450–460

    Article  Google Scholar 

  • Cui X, Boland T (2009) Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials 30:6221–6227

    Article  Google Scholar 

  • Cui H, Nowicki M, Fisher JP, Zhang LG (2017) 3D bioprinting of organ regeneration. Adv Healthc Mater 6(1):1601118

    Article  Google Scholar 

  • Gu Q, Tomaskovic-Crook E, Lozano R, Chen Y, Kapsa RM, Zhou Q, Wallace GE, Crook JM (2016) Stem cell bioprinting: functional 3D neural mini-tissue from gel-based bioink and human neural stem cells. Adv Healthc Mater 5(12):1429–1438

    Article  Google Scholar 

  • Hoch E, Tovar GE, Borchers K (2014) Bioprinting of artificial blood vessels: current approaches towards a demanding goal. Eur J Cardiothorac Surg 46(5):767–778

    Article  Google Scholar 

  • Hospodiuk M, Dey M, Sosnovski D, Osbolat IT (2017) The bioink: a comprehensive review on bioprintable materials. Biotechnol Adv. doi:10.1016/j.biotechadv.12.oo6

    Google Scholar 

  • Jung JW, Lee J-S, Cho D-W (2016) Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs. Sci Report 6:21685

    Article  Google Scholar 

  • Kang H-W, Lee SJ, Ku IK, Kengla C, Yoo JJ, Atala A (2016) A 3D bioprinting system to produce human-scale tissue constructs with structural integrity. Nat Biotechnol 34:312–319

    Article  Google Scholar 

  • Kasza KE, Rowat AC, Liu J, Angelini TE, Brongwynne CP, Koenderink GH, Weitz DA (2007) The cell as a material. Curr Opin Cell Biol 19:101–107

    Article  Google Scholar 

  • Langer R (2007) Tissue engineering: perspectives, challenges, and future directions. Tissue Eng 13:1–2

    Article  Google Scholar 

  • Li J, He L, Zhou C, Zhou Y, Bai Y, Lee FY, Mao JJ (2015) 3D printing for regenerative medicine: from bench to bedside. MRS Bull 40(2):145–154

    Article  Google Scholar 

  • Ma PX, Elisseeff J (eds) (2005) Scaffolding in tissue engineering. CRC Press, Boca Raton

    Google Scholar 

  • Melchelo F, Domingos PW, Neves MA, Klein TJ, Maida J, Bartolo PJ, Hatmacher D (2011) Additive manufacturing of tissue and organs. Prog Polym Sci 37(31):1079–1104

    Google Scholar 

  • Mironov V, Boland T, Trask T, Forgacs G, Markwald RR (2003) Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol 21:157–161

    Article  Google Scholar 

  • Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RP (2009) Organ printing: tissue spheroids as building blocks. Biomaterials 30:2164–2174

    Article  Google Scholar 

  • Murphy SV, Atala A (2014) 3D bio printing of tissue and organs. Nat Biotechnol 32:773–785

    Article  Google Scholar 

  • Ozbolat IT (2017) 3D bioprinting: fundamentals, principles and applications. Academic/Elsevier, New York

    Google Scholar 

  • Radenkovic D, Solak A, Seifalian A (2016) Personalized development of human organs using 3D printing technology. Med Hypotheses 87:30–33

    Article  Google Scholar 

  • Reiffel AJ, Kafka C, Hernandez KA, Popa S, Perez JL, Zhau S, Pramanik S, Brown BN, Ryu WS, Bonassar LJ, Spector JA (2013) High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities. PLoS One 8(2):e56506

    Article  Google Scholar 

  • Sun W, Lai P (2002) Recent development on computer-aided tissue engineering – a review. Comput Methods Prog Biomed 67:85–103

    Article  Google Scholar 

  • Tripathi A, Melo JS (2017) Advances in biomaterials for medical applications, Advanced structural materials, vol 66. Springer, Singapore. Zhang X-F, Huang Y, Guo G, Cui X: Current progress in bioprinting: 227–259

    Book  Google Scholar 

  • Yanez M, Rincon J, Cortez P, Gänthes N, Boland T (2012) Printable cellular scaffold using self-crosslinking agents. J Imaging Sci Technol 56(4):040506-1–040506-5

    Article  Google Scholar 

  • Zhang YS, Yue K, Aleman J, Mollezadeh-Moghaddam K, Bakht SM, Yang J, Jia W, Dell’Erba V, Assawes P, Shin SR, Dokmeci MR, Oklu R (2017) 3D bioprinting for tissue and organ fabrication. Ann Biomed Eng 45(1):148–163

    Article  Google Scholar 

  • Zhu W, Qu X, Ma X, Pater S, Liu J, Wang P, Sun C, Lai E, Gou M, Xu Y, Zhang K, Chen S (2017) Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials 124:106–115

    Article  Google Scholar 

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Correspondence to Lawrence E. Murr .

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Murr, L.E. (2017). Bioprinting and Biofabrication of Organs. In: Handbook of Materials Structures, Properties, Processing and Performance. Springer, Cham. https://doi.org/10.1007/978-3-319-01905-5_36-2

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  • DOI: https://doi.org/10.1007/978-3-319-01905-5_36-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-01905-5

  • Online ISBN: 978-3-319-01905-5

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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Chapter history

  1. Latest

    Bioprinting and Biofabrication of Organs
    Published:
    06 April 2017

    DOI: https://doi.org/10.1007/978-3-319-01905-5_36-2

  2. Original

    Bioprinting and Biofabrication of Organ
    Published:
    10 June 2014

    DOI: https://doi.org/10.1007/978-3-319-01905-5_36-1