Theme: Modeling and Simulations of Drug Product Manufacturing Unit Operations

In this topical collection (17 articles)

1. 

   Research Article

   Coarse-Grained Molecular Dynamics (CG-MD) Simulation of the Encapsulation of Dexamethasone in PSS/PDDA Layer-by-Layer Assembled Polyelectrolyte Nanocapsules

   Daniel P. Otto, Melgardt M. de Villiers Article:292

2. 

   Research Article

   A Software Tool for Lyophilization Primary Drying Process Development and Scale-up Including Process Heterogeneity, I: Laboratory-Scale Model Testing

   Robin Bogner, Emily Gong, William Kessler, Michael Hinds… Article:274

3. 

   Brief/Technical Note

   Highlighting DEM’s Potential to Gauge Mechanistic Attributes of MUPS Tablet and Capsule Formulations

   Shishir Shekhar, Negin Amini, David A. V. Morton, Karen P. Hapgood… Article:271

4. 

   Research Article

   Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for Oral Solid Dosage Manufacturing

   Daniel Mateo-Ortiz, Vladimir Villanueva-Lopez, Shashank Venkat Muddu… Article:249

5. 

   Research Article

   Predictive Approach to Understand and Eliminate Tablet Breakage During Film Coating

   William R. Ketterhagen, Jeffery Larson, Kevin Spence, Jared A. Baird Article:178

6. 

   Research Article

   Scale-up of Fluid Bed Granulation Using a Scale-Independent Parameter and a Process Model

   Emmanuela Gavi, Angela Dischinger Article:148

7. Research Article

   Impact of Critical Material Attributes (CMAs)-Particle Shape on Miniature Pharmaceutical Unit Operations

   Mohammad A. Azad, Gerard Capellades, Allison B. Wang, David M. Klee… Article:98

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8. 

   Research Article-

   A Multi-variate Mathematical Model for Simulating the Granule Size Distribution in Roller Compaction-Milling Process

   Hossein Amini, Ilgaz Akseli Article:97

9. Editorial

   Pharmaceutical Process Modeling

   Alexander Russell, Maxx Capece Article:91

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10. 

    Research Article

    A CFD Digital Twin to Understand Miscible Fluid Blending

    John Thomas, Kushal Sinha, Gayathri Shivkumar, Lei Cao, Marina Funck… Article:91

11. 

    Research Article

    Applications of the Linear Mass-Sectional Breakage Population Balance to Various Milling Process Configurations

    Russell B. Diemer Jr Article:86

12. Review Article

    Direct Compaction Drug Product Process Modeling

    Alexander Russell, John Strong, Sean Garner, William Ketterhagen… Article:67

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13. Research Article

    Evaluation of Microwave Vacuum Drying as an Alternative to Freeze-Drying of Biologics and Vaccines: the Power of Simple Modeling to Identify a Mechanism for Faster Drying Times Achieved with Microwave

    Akhilesh Bhambhani, Justin Stanbro, Daniel Roth, Elizabeth Sullivan… Article:52

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14. 

    Research Article

    Development of an RTD-Based Flowsheet Modeling Framework for the Assessment of In-Process Control Strategies

    Geng Tian, Abdollah Koolivand, Zongyu Gu, Michael Orella, Ryan Shaw… Article:25

15. 

    Research Article

    A Novel Computational Approach Coupled with Machine Learning to Predict the Extent of Agglomeration in Particulate Processes

    Kushal Sinha, Eric Murphy, Prashant Kumar, Kirsten A. Springer… Article:18

16. Research Article

    Validating a Numerical Simulation of the ConsiGma(R) Coater

    Peter Boehling, Dalibor Jacevic, Frederik Detobel, James Holman… Article:10

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17. 

    Review Article

    Mechanistic Modeling of Wet Stirred Media Milling for Production of Drug Nanosuspensions

    E. Bilgili, G. Guner Article:2