Neurotherapeutics

, Volume 14, Issue 1, pp 4–10

Magnetoencephalography and New Imaging Modalities in Epilepsy

  • Jessica Falco-Walter
  • Christian Owen
  • Mishu Sharma
  • Christopher Reggi
  • Mandy Yu
  • Travis R. Stoub
  • Michael A. Stein
Review

DOI: 10.1007/s13311-016-0506-7

Cite this article as:
Falco-Walter, J., Owen, C., Sharma, M. et al. Neurotherapeutics (2017) 14: 4. doi:10.1007/s13311-016-0506-7

Abstract

The success of epilepsy surgery is highly dependent on correctly identifying the entire epileptogenic region. Current state-of-the-art for localizing the extent of surgically amenable areas involves combining high resolution three-dimensional magnetic resonance imaging (MRI) with electroencephalography (EEG) and magnetoencephalography (MEG) source modeling of interictal epileptiform activity. Coupling these techniques with newer quantitative structural MRI techniques, such as cortical thickness measurements, however, may improve the extent to which the abnormal epileptogenic region can be visualized. In this review we assess the utility of EEG, MEG and quantitative structural MRI methods for the evaluation of patients with epilepsy and introduce a novel method for the co-localization of a structural MRI measurement to MEG and EEG source modeling. When combined, these techniques may better identify the extent of abnormal structural and functional areas in patients with medically intractable epilepsy.

Keywords

MEG EEG MRI Epilepsy Imaging Focal cortical dysplasia 

Supplementary material

13311_2016_506_MOESM1_ESM.pdf (1.2 mb)
ESM 1(PDF 1224 kb)

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2017

Authors and Affiliations

  • Jessica Falco-Walter
    • 1
  • Christian Owen
    • 2
  • Mishu Sharma
    • 3
  • Christopher Reggi
    • 2
  • Mandy Yu
    • 2
  • Travis R. Stoub
    • 2
  • Michael A. Stein
    • 4
  1. 1.Department of Neurology and Neurological SciencesStanford University School of MedicineStanfordUSA
  2. 2.Department of Neurological SciencesRush University Medical CenterChicagoUSA
  3. 3.Rush Medical CollegeChicagoUSA
  4. 4.Department of NeurologyBarrow Neurological InstitutePhoenixUSA