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Optimization of Mixing Parameters for α-Tocopherol Nanodispersions Prepared Using Solvent Displacement Method

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Journal of the American Oil Chemists' Society

Abstract

A bottom-up approach based on a solvent displacement technique was used for the production of α-tocopherol nanodispersions. Response surface methodology was utilized to study the effect of the mixing conditions of organic and aqueous phases, namely, mixing speed (1 × 100–6 × 100 rpm) and mixing time (30–150 s) on the average particle size (nm), polydispersity index and α-tocopherol concentration (mg/L) of the nanodispersions. Second order regression models, with high coefficient of determination values (R 2 > 0.94 and adjusted R 2 > 0.79), were significantly (p < 0.05) fitted for predicting the α-tocopherol nanodispersion characteristics as functions of mixing parameters. A multiple optimization procedure presented the optimum mixing speed and time as 3.8 × 100 rpm and 70 s, respectively. The statistically insignificant differences between experimental and predicted values of studied responses, verified the satisfactoriness of the models found for explaining the variation of produced nanodispersions, as a function of mixing conditions.

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Acknowledgments

Financial support of this work by INSF (Iran National Science Foundation) through the Science Fund (91002606) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Engineering, College of Chemical Engineering, East Azarbayjan Science and Research Branch, Islamic Azad University, Tabriz, Iran

    Navideh Anarjan & Naghmeh Jaberi

  2. Food and Hygiene Control Laboratory, Deputy for Food and Drug, Urmia University of Medical Sciences, Urmia, Iran

    Samal Yeganeh-Zare, Elham Banafshehchin & Amir Rahimirad

  3. Department of Chemical Engineering, Sahand University of Technology, Tabriz, Iran

    Hoda Jafarizadeh-Malmiri

Authors
  1. Navideh Anarjan
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  2. Naghmeh Jaberi
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  3. Samal Yeganeh-Zare
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  4. Elham Banafshehchin
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  5. Amir Rahimirad
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  6. Hoda Jafarizadeh-Malmiri
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Correspondence to Hoda Jafarizadeh-Malmiri.

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Anarjan, N., Jaberi, N., Yeganeh-Zare, S. et al. Optimization of Mixing Parameters for α-Tocopherol Nanodispersions Prepared Using Solvent Displacement Method. J Am Oil Chem Soc 91, 1397–1405 (2014). https://doi.org/10.1007/s11746-014-2482-6

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  • DOI: https://doi.org/10.1007/s11746-014-2482-6

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