Overview
- Presents current up-to-date methodologies
- Features tips on trouble shooting and avoiding known pitfalls
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 1017)
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Table of contents (18 protocols)
Keywords
About this book
The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences. Those tandem repeats located as codons within open reading frames encode amino acid runs, such as polyglutamine and polyalanine. Tandem repeats have not only been implicated in biological evolution, development and function but also in a large collection of human disorders. In Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols, expert researchers in the field detail many methods covering the analysis of tandem repeats in DNA, RNA and protein, in healthy and diseased states. This will include molecular genetics, molecular biology, biochemistry, proteomics, biophysics, cell biology, and molecular and cellular approaches to animal models of tandem repeat disorders. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoratative and Practical, Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols aids scientists in continuing to study the unique methodological challenges that come from repetitive DNA and poly-amino acid sequences.
Editors and Affiliations
Bibliographic Information
Book Title: Tandem Repeats in Genes, Proteins, and Disease
Book Subtitle: Methods and Protocols
Editors: Danny M. Hatters, Anthony J. Hannan
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-62703-438-8
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-62703-437-1Published: 30 May 2013
Softcover ISBN: 978-1-4939-6300-3Published: 23 August 2016
eBook ISBN: 978-1-62703-438-8Published: 30 May 2013
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XI, 258
Number of Illustrations: 32 b/w illustrations, 23 illustrations in colour
Topics: Human Genetics, Gene Function
Industry Sectors: Biotechnology, Pharma