Overview
- Editors:
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Juan A. Rosado
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Depto. Fisiología, University of Extremadura, Cáceres, Spain
- Provides an extensive overview of the mechanisms underlying calcium entry in non-excitable cells
- Includes relevant background information, critical analysis of the current observations and directions for future research
- Written in a concise manner by leading scientists in the field
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Table of contents (19 chapters)
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Store-Operated Calcium Entry
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- Letizia Albarran, Jose J. Lopez, Ginés M. Salido, Juan A. Rosado
Pages 3-24
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- Irene Frischauf, Marc Fahrner, Isaac Jardín, Christoph Romanin
Pages 25-46
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- Dong Min Shin, Aran Son, Seonghee Park, Min Seuk Kim, Malini Ahuja, Shmuel Muallem
Pages 47-66
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- Alan G. S. Harper, Stewart O. Sage
Pages 67-85
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- Hwei Ling Ong, Lorena Brito de Souza, Indu S. Ambudkar
Pages 87-109
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- Tarik Smani, Alejandro Domínguez-Rodriguez, Paula Callejo-García, Juan A. Rosado, Javier Avila-Medina
Pages 111-131
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- Alejandro Berna-Erro, Isaac Jardín, Tarik Smani, Juan A. Rosado
Pages 157-181
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Non-capacitative Ca2+ Entry Pathways
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Front Matter
Pages 183-183
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- Guillermo Vazquez, Sumeet Solanki, Prabhatachandra Dube, Kathryn Smedlund, Prince Ampem
Pages 185-199
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- Alexandre Bouron, Sylvain Chauvet, Stuart Dryer, Juan A. Rosado
Pages 201-249
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- Xuexin Zhang, Amy M. Spinelli, Timothy Masiello, Mohamed Trebak
Pages 251-264
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- Francisco J. Taberner, Isabel Devesa, Antonio Ferrer-Montiel
Pages 265-304
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- Martyn P. Mahaut-Smith, Kirk A. Taylor, Richard J. Evans
Pages 305-329
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Role of Cellular Microdomains and Organelles in Calcium Entry
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Front Matter
Pages 331-331
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- Ziane Elaib, Francois Saller, Regis Bobe
Pages 333-352
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- Jonathan Pacheco, Josué O. Ramírez-Jarquín, Luis Vaca
Pages 353-378
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About this book
Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channelsas the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.
Editors and Affiliations
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Depto. Fisiología, University of Extremadura, Cáceres, Spain
Juan A. Rosado