Abstract
The information from anomalous scattering and isomorphous replacement are complementary. Ways in which these two sources of information can be combined to facilitate the determination of the crystal structures of macromolecules are reviewed. The use of a single isomorphous replacement leads to an ambiguous phase determination, but this ambiguity can be resolved by incorporation of data from anomalous scattering. Likewise, information from isomorphous replacement and anomalous scattering can be combined to assist in the location of heavy atoms. This chapter is also available as HTML from the International Tables Online site hosted by the IUCr.
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© 2006 International Union of Crystallography
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Matthews, B.W. (2006). Heavy-atom location and phase determination with single-wavelength diffraction data. In: Rossmann, M.G., Arnold, E. (eds) International Tables for Crystallography Volume F: Crystallography of biological macromolecules. International Tables for Crystallography, vol F. Springer, Dordrecht. https://doi.org/10.1107/97809553602060000685
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DOI: https://doi.org/10.1107/97809553602060000685
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-6857-1
Online ISBN: 978-1-4020-5416-7
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)