Abstract
In order to obtain phase information from isomorphous replacement (or from anomalous dispersion), it is necessary to locate the atomic positions of the heavy-atom (or anomalous) scatterers. The topics covered in this chapter include: the origin of the phase problem; the Patterson function; difference Fourier maps; treatment of errors; automated search procedures; and special complications such as lack of isomorphism, space-group problems and high levels of substitution. This chapter is also available as HTML from the International Tables Online site hosted by the IUCr.
This is a preview of subscription content, log in via an institution.
Preview
Unable to display preview. Download preview PDF.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 International Union of Crystallography
About this entry
Cite this entry
Stubbs, M.T., Huber, R. (2006). Locating heavy-atom sites. In: Rossmann, M.G., Arnold, E. (eds) International Tables for Crystallography Volume F: Crystallography of biological macromolecules. International Tables for Crystallography, vol F. Springer, Dordrecht. https://doi.org/10.1107/97809553602060000680
Download citation
DOI: https://doi.org/10.1107/97809553602060000680
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-6857-1
Online ISBN: 978-1-4020-5416-7
eBook Packages: Springer Book Archive