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Disorders of Sleep and Cardiovascular Disease

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Handbook of Psychocardiology

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Abstract

Despite decades of effort, one of the greatest mysteries in biology is to understand sleep. Sleep is more than simply rest. Depriving someone of sleep has powerful adverse effects on their mental, metabolic, and cardiovascular health. The timing of sleep also plays an important role in terms of the onset of cardiovascular events. Finally, the effects of sleep on ventilation and the downstream effects of sleep apnea in the pathogenesis of all cardiovascular conditions have come of age in the evidence-based medicine field.

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References

  • Armstrong, S. M., Cassone, V. M., Chesworth, M. J., Redman, J. R., & Short, R. V. (1986). Synchronization of mammalian circadian rhythms by melatonin. Journal of Neural Transmission, 21, 375–394.

    PubMed  Google Scholar 

  • Aserinsky, E., & Kleitman, N. (1953). Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science (New York, NY), 118(3062), 273–274.

    Article  Google Scholar 

  • Ayas, N. T., White, D. P., Manson, J. E., Stampfer, M. J., Speizer, F. E., Malhotra, A., et al. (2003). A prospective study of sleep duration and coronary heart disease in women. Archives of Internal Medicine, 163(2), 205–209.

    Article  PubMed  Google Scholar 

  • Bazzano, L. A., Khan, Z., Reynolds, K., & He, J. (2007). Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea. Hypertension, 50(2), 417–423.

    Article  PubMed  Google Scholar 

  • Bixler, E. O., Vgontzas, A. N., Lin, H. M., Ten Have, T., Leiby, B. E., Vela-Bueno, A., et al. (2000). Association of hypertension and sleep-disordered breathing. Archives of Internal Medicine, 160(15), 2289–2295. Aug 14–28.

    Article  PubMed  Google Scholar 

  • Bixler, E. O., Vgontzas, A. N., Lin, H. M., Calhoun, S. L., Vela-Bueno, A., & Kales, A. (2005). Excessive daytime sleepiness in a general population sample: The role of sleep apnea, age, obesity, diabetes, and depression. The Journal of Clinical Endocrinology and Metabolism, 90(8), 4510–4515.

    Article  PubMed  Google Scholar 

  • Boggild, H., & Knutsson, A. (1999). Shift work, risk factors and cardiovascular disease. Scandinavian Journal of Work, Environment & Health, 25(2), 85–99.

    Article  Google Scholar 

  • Borbely, A. A. (1982). A two process model of sleep regulation. Human Neurobiology, 1(3), 195–204.

    PubMed  Google Scholar 

  • Chami, H. A., Devereux, R. B., Gottdiener, J. S., Mehra, R., Roman, M. J., Benjamin, E. J., et al. (2008). Left ventricular morphology and systolic function in sleep-disordered breathing: The Sleep Heart Health Study. Circulation, 117(20), 2599–2607.

    Article  PubMed  PubMed Central  Google Scholar 

  • Craig, S., Pepperell, J. C., Kohler, M., Crosthwaite, N., Davies, R. J., & Stradling, J. R. (2009). Continuous positive airway pressure treatment for obstructive sleep apnoea reduces resting heart rate but does not affect dysrhythmias: A randomised controlled trial. Journal of Sleep Research, 18(3), 329–336.

    Article  PubMed  Google Scholar 

  • Davies, R. J., Crosby, J., Vardi-Visy, K., Clarke, M., & Stradling, J. R. (1994). Non-invasive beat to beat arterial blood pressure during non-REM sleep in obstructive sleep apnoea and snoring. Thorax, 49(4), 335–339.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O’Donnell, C. P. (2010). Pathophysiology of sleep apnea. Physiological Reviews, 90(1):47–112. Jan.

    Google Scholar 

  • Dinges, D. F., Pack, F., Williams, K., Gillen, K. A., Powell, J. W., Ott, G. E., et al. (1997). Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 hours per night. Sleep, 20(4), 267–277.

    PubMed  Google Scholar 

  • Earley, C. J. (2003). Clinical practice. Restless legs syndrome. The New England Journal of Medicine, 348(21), 2103–2109.

    Article  PubMed  Google Scholar 

  • Everson, C. A., Bergmann, B. M., & Rechtschaffen, A. (1989). Sleep deprivation in the rat: III. Total sleep deprivation. Sleep, 12(1), 13–21.

    PubMed  Google Scholar 

  • Flemons, W. W. (2002). Clinical practice. Obstructive sleep apnea. The New England Journal of Medicine, 347(7), 498–504.

    Article  PubMed  Google Scholar 

  • Friedman, M., Ibrahim, H., & Bass, L. (2002). Clinical staging for sleep-disordered breathing. Otolaryngology and Head and Neck Surgery, 127(1), 13–21.

    Article  Google Scholar 

  • Gami, A. S., Howard, D. E., Olson, E. J., & Somers, V. K. (2005). Day-night pattern of sudden death in obstructive sleep apnea. The New England Journal of Medicine, 352(12), 1206–1214.

    Article  PubMed  Google Scholar 

  • Gangwisch, J. E., Malaspina, D., Boden-Albala, B., & Heymsfield, S. B. (2005). Inadequate sleep as a risk factor for obesity: Analyses of the NHANES I. Sleep, 28(10), 1289–1296.

    PubMed  Google Scholar 

  • Gotsopoulos, H., Kelly, J. J., & Cistulli, P. A. (2004). Oral appliance therapy reduces blood pressure in obstructive sleep apnea: A randomized, controlled trial. Sleep, 27(5), 934–941.

    PubMed  Google Scholar 

  • Gottlieb, D. J., Yenokyan, G., Newman, A. B., O’Connor, G. T., Punjabi, N. M., Quan, S. F., et al. (2010). Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: The sleep heart health study. Circulation, 122(4):352–360.

    Google Scholar 

  • Hamilton, G. S., & Naughton, M. T. (2013). Impact of obstructive sleep apnoea on diabetes and cardiovascular disease. The Medical Journal of Australia, 199(8):S27–S30.

    Google Scholar 

  • Hung, J., Whitford, E. G., Parsons, R. W., & Hillman, D. R. (1990). Association of sleep apnoea with myocardial infarction in men. Lancet, 336(8710), 261–264.

    Article  PubMed  Google Scholar 

  • Jennum, P., & Kjellberg, J. (2011). Health, social and economical consequences of sleep-disordered breathing: A controlled national study. Thorax, 66(7):560–566.

    Google Scholar 

  • Kanagala, R., Murali, N. S., Friedman, P. A., Ammash, N. M., Gersh, B. J., Ballman, K. V., et al. (2003). Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation, 107(20), 2589–2594.

    PubMed  Google Scholar 

  • Kee, K., & Naughton, M. T. (2009). Heart failure and sleep-disordered breathing: Mechanisms, consequences and treatment. Current Opinion in Pulmonary Medicine, 15(6), 565–570.

    Article  PubMed  Google Scholar 

  • Kushida, C. A., Bergmann, B. M., & Rechtschaffen, A. (1989). Sleep deprivation in the rat: IV. Paradoxical sleep deprivation. Sleep, 12(1), 22–30.

    PubMed  Google Scholar 

  • Landrigan, C. P., Rothschild, J. M., Cronin, J. W., Kaushal, R., Burdick, E., Katz, J. T., et al. (2004). Effect of reducing interns’ work hours on serious medical errors in intensive care units. The New England Journal of Medicine, 351(18), 1838–1848.

    Article  PubMed  Google Scholar 

  • Lavie, P., Lavie, L., & Herer, P. (2005). All-cause mortality in males with sleep apnoea syndrome: Declining mortality rates with age. The European Respiratory Journal, 25(3), 514–520.

    Article  PubMed  Google Scholar 

  • Lee, S. A., Amis, T. C., Byth, K., Larcos, G., Kairaitis, K., Robinson, T. D., et al. (2008). Heavy snoring as a cause of carotid artery atherosclerosis. Sleep, 31(9), 1207–1213.

    PubMed  PubMed Central  Google Scholar 

  • Levy, P., & McNicholas, W. T. (2013). Sleep apnoea and hypertension: Time for recommendations. The European Respiratory Journal, 41(3):505–506.

    Google Scholar 

  • Lockley, S. W., Cronin, J. W., Evans, E. E., Cade, B. E., Lee, C. J., Landrigan, C. P., et al. (2004). Effect of reducing interns’ weekly work hours on sleep and attentional failures. The New England Journal of Medicine, 351(18), 1829–1837.

    Article  PubMed  Google Scholar 

  • Logan, A. G., Perlikowski, S. M., Mente, A., Tisler, A., Tkacova, R., Niroumand, M., et al. (2001). High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. Journal of Hypertension, 19(12), 2271–2277.

    Article  PubMed  Google Scholar 

  • Loke, Y. K., Brown, J. W., Kwok, C. S., Niruban, A., & Myint, P. K. (2012). Association of obstructive sleep apnea with risk of serious cardiovascular events: A systematic review and meta-analysis. Circular Cardiovascular Quality Outcomes, 5(5):720–728. 1 Sep.

    Google Scholar 

  • Mahowald, M. W., & Schenck, C. H. (2005). Insights from studying human sleep disorders. Nature, 437(7063), 1279–1285.

    Article  PubMed  Google Scholar 

  • Maimon, N., & Hanly, P. J. (2010). Does snoring intensity correlate with the severity of obstructive sleep apnea? J Clin Sleep Med, 6(5):475–478.

    Google Scholar 

  • Majde, J. A., & Krueger, J. M. (2005). Links between the innate immune system and sleep. The Journal of Allergy and Clinical Immunology, 116(6), 1188–1198.

    Article  PubMed  Google Scholar 

  • Mansfield, D. R., Gollogly, N. C., Kaye, D. M., Richardson, M., Bergin, P., & Naughton, M. T. (2004). Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. American Journal of Respiratory and Critical Care Medicine, 169(3), 361–366.

    Article  PubMed  Google Scholar 

  • Marshall, N. S., Wong, K. K., Cullen, S. R., Knuiman, M. W., & Grunstein, R. R. (2008). Snoring is not associated with all-cause mortality, incident cardiovascular disease, or stroke in the Busselton Health Study. Sleep, 35(9):1235–1240.

    Google Scholar 

  • Martinez-Garcia, M. A., Capote, F., Campos-Rodriguez, F., Lloberes, P., Diaz de Atauri, M. J., Somoza, M., et al. (2013). Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: The HIPARCO randomized clinical trial. JAMA, 310(22):2407–2415. 11 Dec.

    Google Scholar 

  • Mehra, R., Benjamin, E. J., Shahar, E., Gottlieb, D. J., Nawabit, R., Kirchner, H. L., et al. (2006). Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study. American Journal of Respiratory and Critical Care Medicine, 173(8), 910–916.

    Article  PubMed  PubMed Central  Google Scholar 

  • Muller, J. E., Tofler, G. H., & Stone, P. H. (1989). Circadian variation and triggers of onset of acute cardiovascular disease. Circulation, 79(4), 733–743.

    Article  PubMed  Google Scholar 

  • Munoz, R., Duran-Cantolla, J., Martinez-Vila, E., Gallego, J., Rubio, R., Aizpuru, F., et al. (2006). Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke; a Journal of Cerebral Circulation, 37(9), 2317–2321.

    Article  PubMed  Google Scholar 

  • Naughton, M. T. (2012). Cheyne-stokes respiration: Friend or foe? Thorax, 67(4):357–360. Apr.

    Google Scholar 

  • O’Connor, G. T., Caffo, B., Newman, A. B., Quan, S. F., Rapoport, D. M., Redline, S., et al. (2009). Prospective study of sleep-disordered breathing and hypertension: The Sleep Heart Health Study. American Journal of Respiratory and Critical Care Medicine, 179(12), 1159–1164.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pack, A. I., Maislin, G., Staley, B., Pack, F. M., Rogers, W. C., George, C. F., et al. (2006). Impaired performance in commercial drivers: Role of sleep apnea and short sleep duration. American Journal of Respiratory and Critical Care Medicine, 174(4), 446–454.

    Article  PubMed  PubMed Central  Google Scholar 

  • Parra, O., Sanchez-Armengol, A., Bonnin, M., Arboix, A., Campos-Rodriguez, F., Perez-Ronchel, J., et al. (2011). Early treatment of obstructive apnoea and stroke outcome: A randomised controlled trial. The European Respiratory Journal, 37(5):1128–1136. May.

    Google Scholar 

  • Peker, Y., Hedner, J., Norum, J., Kraiczi, H., & Carlson, J. (2002). Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: A 7-year follow-up. American Journal of Respiratory and Critical Care Medicine, 166(2), 159–165.

    Article  PubMed  Google Scholar 

  • Pepin, J. L., Tamisier, R., Barone-Rochette, G., Launois, S. H., Levy, P., & Baguet, J. P. (2010). Comparison of continuous positive airway pressure and valsartan in hypertensive patients with sleep apnea. American Journal of Respiratory and Critical Care Medicine, 182(7):954–960.

    Google Scholar 

  • Peppard, P. E., Young, T., Barnet, J. H., Palta, M., Hagen, E. W., & Hla, K. M. (2013). Increased prevalence of sleep-disordered breathing in adults. American Journal of Epidemiology, 177(9):1006–1014.

    Google Scholar 

  • Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000). Prospective study of the association between sleep-disordered breathing and hypertension. New England Journal of Medicine, 342(19), 1378–1384.

    Article  PubMed  Google Scholar 

  • Pinna, G. D., Maestri, R., Mortara, A., Johnson, P., Andrews, D., Ponikowski, P., et al. (2010). Long-term time-course of nocturnal breathing disorders in heart failure patients. The European Respiratory Journal, 35(2):361–367.

    Google Scholar 

  • Punjabi, N. M., Caffo, B. S., Goodwin, J. L., Gottlieb, D. J., Newman, A. B., O’Connor, G. T., et al. (2009). Sleep-disordered breathing and mortality: A prospective cohort study. PLoS Medicine, 6(8), e1000132.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rechtschaffen, A., & Bergmann, B. M. (2002). Sleep deprivation in the rat: An update of the 1989 paper. Sleep, 25(1), 18–24.

    PubMed  Google Scholar 

  • Rechtschaffen, A., Bergmann, B. M., Everson, C. A., Kushida, C. A., & Gilliland, M. A. (2002). Sleep deprivation in the rat: X. Integration and discussion of the findings. 1989. Sleep, 25(1), 68–87.

    PubMed  Google Scholar 

  • Redline, S., Yenokyan, G., Gottlieb, D. J., Shahar, E., O’Connor, G. T., Resnick, H. E., et al. (2010). Obstructive sleep apnea-hypopnea and incident stroke: The sleep heart health study. American Journal of Respiratory and Critical Care Medicine, 182(2):269–277.

    Google Scholar 

  • Rothwell, P. M., Howard, S. C., Dolan, E., O’Brien, E., Dobson, J. E., Dahlof, B., et al. (2010). Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurology, 9(5):469–480.

    Google Scholar 

  • Ryan, C. M., Usui, K., Floras, J. S., & Bradley, T. D. (2005). Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax, 60(9), 781–785.

    Article  PubMed  PubMed Central  Google Scholar 

  • Saper, C. B., Scammell, T. E., & Lu, J. (2005). Hypothalamic regulation of sleep and circadian rhythms. Nature, 437(7063), 1257–1263.

    Article  PubMed  Google Scholar 

  • Shahar, E., Whitney, C. W., Redline, S., Lee, E. T., Newman, A. B., Nieto, F. J., et al. (2001). Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the Sleep Heart Health Study. American Journal of Respiratory and Critical Care Medicine, 163(1), 19–25.

    Article  PubMed  Google Scholar 

  • Shanoudy, H., Soliman, A., Raggi, P., Liu, J. W., Russell, D. C., & Jarmukli, N. F. (1998). Prevalence of patent foramen ovale and its contribution to hypoxemia in patients with obstructive sleep apnea. Chest, 113(1), 91–96.

    Article  PubMed  Google Scholar 

  • Spiegel, K., Leproult, R., & Van Cauter, E. (1999). Impact of sleep debt on metabolic and endocrine function. Lancet, 354(9188), 1435–1439.

    Article  PubMed  Google Scholar 

  • Spiegel, K., Sheridan, J. F., & Van Cauter, E. (2002). Effect of sleep deprivation on response to immunization. JAMA, 288(12), 1471–1472.

    Article  PubMed  Google Scholar 

  • Spiegel, K., Tasali, E., Penev, P., & Van Cauter, E. (2004). Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Annals of Internal Medicine, 141(11), 846–850.

    Article  PubMed  Google Scholar 

  • Stevenson, I. H., Teichtahl, H., Cunnington, D., Ciavarella, S., Gordon, I., & Kalman, J. M. (2008). Prevalence of sleep disordered breathing in paroxysmal and persistent atrial fibrillation patients with normal left ventricular function. European Heart Journal, 29(13), 1662–1669.

    Article  PubMed  Google Scholar 

  • Stickgold, R. (2005). Sleep-dependent memory consolidation. Nature, 437(7063), 1272–1278.

    Article  PubMed  Google Scholar 

  • Suzuki, M., Ogawa, H., Okabe, S., Horiuchi, A., Okubo, M., Ikeda, K., et al. (2005). Digital recording and analysis of esophageal pressure for patients with obstructive sleep apnea-hypopnea syndrome. Sleep & Breathing = Schlaf & Atmung, 9(2), 64–72.

    Article  Google Scholar 

  • Taffinder, N. J., McManus, I. C., Gul, Y., Russell, R. C., & Darzi, A. (1998). Effect of sleep deprivation on surgeons’ dexterity on laparoscopy simulator. Lancet, 352(9135), 1191.

    Article  PubMed  Google Scholar 

  • Tamakoshi, A., & Ohno, Y. (2004). Self-reported sleep duration as a predictor of all-cause mortality: Results from the JACC study, Japan. Sleep, 27(1), 51–54.

    PubMed  Google Scholar 

  • Trinder, J., Kleiman, J., Carrington, M., Smith, S., Breen, S., Tan, N., et al. (2001). Autonomic activity during human sleep as a function of time and sleep stage. Journal of Sleep Research, 10(4), 253–264.

    Article  PubMed  Google Scholar 

  • Tsai, W. H., Remmers, J. E., Brant, R., Flemons, W. W., Davies, J., & Macarthur, C. (2003). A decision rule for diagnostic testing in obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine, 167(10), 1427–1432.

    Article  PubMed  Google Scholar 

  • Van Dongen, H. P., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003). The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep, 26(2), 117–126.

    PubMed  Google Scholar 

  • Wang, H., Parker, J. D., Newton, G. E., Floras, J. S., Mak, S., Chiu, K. L., et al. (2007). Influence of obstructive sleep apnea on mortality in patients with heart failure. Journal of the American College of Cardiology, 49(15), 1625–1631.

    Article  PubMed  Google Scholar 

  • Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., et al. (2013). Sleep drives metabolite clearance from the adult brain. Science (New York, NY), 342(6156):373–377.

    Google Scholar 

  • Yumino, D., Wang, H., Floras, J. S., Newton, G. E., Mak, S., Ruttanaumpawan, P., et al. (2009). Prevalence and physiological predictors of sleep apnea in patients with heart failure and systolic dysfunction. Journal of Cardiac Failure, 15(4), 279–285.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia

    Matthew T. Naughton

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  1. Matthew T. Naughton
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Correspondence to Matthew T. Naughton .

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Editors and Affiliations

  1. Monash Cardiovascular Research Centre, Monash University, Melbourne, Victoria, Australia

    Marlies E. Alvarenga

  2. ANU Medical School, Australia National University, Canberra, Aust Capital Terr, Australia

    Don Byrne

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Naughton, M.T. (2016). Disorders of Sleep and Cardiovascular Disease. In: Alvarenga, M., Byrne, D. (eds) Handbook of Psychocardiology. Springer, Singapore. https://doi.org/10.1007/978-981-287-206-7_20

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