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Active Pharmaceutical Ingredient Ionic Liquid: A New Platform for the Pharmaceutical Industry

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Encyclopedia of Ionic Liquids

Introduction

An active pharmaceutical ingredient (API) is the primary biologically active component of a medical drug formulation that is responsible for the therapeutic effect. In ancient times, when the molecular structure and identity of the APIs were unknown, remedies composed of plants, animal by-products, and even minerals were utilized to heal, treat, and prevent the spread of disease. With the advancement of civilization, the field of medicine made fast progress, and APIs were synthesized rather being extracted from natural sources. Aspirin is generally considered the first synthetic drug, although others describe chloral hydrate as the first synthetic drug in medical history [1].

The pharmacokinetics and pharmacodynamics of an API, which are influenced by their structure, mostly govern the therapeutic efficiency, and owing to this, APIs have various chemical functional groups. These functional groups are usually capable of forming strong inter-/intramolecular interactions via...

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Author information

Authors and Affiliations

  1. College of Arts and Sciences, The University of Alabama, Tuscaloosa, AL, USA

    Hemant Choudhary, Kai Li & Robin D. Rogers

  2. Joint BioEnergy Institute and Sandia National Laboratories, Emeryville, CA, USA

    Hemant Choudhary

  3. 525 Solutions, Inc., Tuscaloosa, AL, USA

    Robin D. Rogers

  4. Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA

    Kai Li

Authors
  1. Hemant Choudhary
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  2. Kai Li
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  3. Robin D. Rogers
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Corresponding author

Correspondence to Robin D. Rogers .

Editor information

Editors and Affiliations

  1. Institute of Process Engineering, Chinese Academy of Science, Institute of Process Engineering, Beijing, China

    Suojiang Zhang

Section Editor information

  1. No affiliation provided

    Zhonghao Li

  2. No affiliation provided

    Maya Guncheva

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© 2019 Springer Nature Singapore Pte Ltd.

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Choudhary, H., Li, K., Rogers, R.D. (2019). Active Pharmaceutical Ingredient Ionic Liquid: A New Platform for the Pharmaceutical Industry. In: Zhang, S. (eds) Encyclopedia of Ionic Liquids. Springer, Singapore. https://doi.org/10.1007/978-981-10-6739-6_3-1

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  • DOI: https://doi.org/10.1007/978-981-10-6739-6_3-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6739-6

  • Online ISBN: 978-981-10-6739-6

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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