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Amorphous Ionic Liquid Strategies for Pharmaceutical Application

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Encyclopedia of Ionic Liquids

Introduction

Ionic liquids (ILs) are salts with a melting point (Tm) or a glass transition (Tg) temperature below 100 °C [1]. Since the first description of air- and water-stable imidazolium ILs in 1992, the field has diverged into different applications. The first generation of ILs are solvents with tunable physical properties in chemical synthesis deploying their nonvolatile nature and thermal stability. The second generation of ILs are solvents tailoring chemical reactivity and solvation, thereby expanding chemical synthesis into liquid crystal development, biotechnology, analytics, extraction, and other applications. The third generation has been introduced as impacting biological properties for active pharmaceutical ingredients (API), e.g., when profiling APIs as IL through counterion design in an effort to control physical-chemical and pharmaceutical properties (e.g., dissolution rate) or providing additional functionality by using biologically active counterions (Fig. 1). ILs...

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Authors and Affiliations

  1. Institute for Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany

    Marco Saedtler & Lorenz Meinel

Authors
  1. Marco Saedtler
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  2. Lorenz Meinel
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Corresponding author

Correspondence to Lorenz Meinel .

Editor information

Editors and Affiliations

  1. Institute of Process Engineering, Chinese Academy of Science, Institute of Process Engineering, Beijing, China

    Suojiang Zhang

Section Editor information

  1. Section 12 Emerging Applications of Ionic Liquids (Pharmacology, Food Science, Agriculture, Nuclear Science Technology, Optics), Shandong University, Jinan, China

    Zhonghao Li

  2. Institute of Organic Chemistry, BAS, Sofia, Bulgaria

    Maya Guncheva

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Saedtler, M., Meinel, L. (2019). Amorphous Ionic Liquid Strategies for Pharmaceutical Application. In: Zhang, S. (eds) Encyclopedia of Ionic Liquids. Springer, Singapore. https://doi.org/10.1007/978-981-10-6739-6_2-1

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  • DOI: https://doi.org/10.1007/978-981-10-6739-6_2-1

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  • Print ISBN: 978-981-10-6739-6

  • Online ISBN: 978-981-10-6739-6

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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