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Microfluidic and Nanomaterial Approach for Virology

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Handbook of Single Cell Technologies

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Abstract

Viral infectious diseases can erupt rapidly and are capable of causing massive health issues. Recent evidence on their high specificity over host species and cell type have fueled research into decoding host–viral interaction. The conventional approach relies on cell culturing-plate and multiwell plate-based analysis, which not only utilizes a large amount of reagents but are also population biased and gives ensemble measurement of biological assay. The animal model does not perfectly recapitulate human disease nor do they provide a point of care analysis. Studying the direct interaction between the virus and the host cell remain challenging. The researcher, therefore, has addressed these challenges using a microfluidic device, which promises high-throughput analysis, analysis at the single-cell level, and small consumption of reagents. These features intensify the understanding of various biological interactions in terms of single-cell heterogeneity in a rapid, accurate, and cost-effective manner. While conventional methods will continue to serve biology and virology well, we envisage that microfluidic platforms for viral infections at a single-cell level will be an impressive method to develop an antiviral drug, discover essential proteins for infection, and to understand viral mutants. This chapter emphasizes the various micro and nanodevice developed for the detection and capture of viruses. In addition, it also deals with an understanding of host–viral interactions and comments on how this understanding might give profound resolution to biological research as well as to the biomedical approach.

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Authors and Affiliations

  1. Chungnam National University, Daejeon, Republic of Korea

    Reya Ganguly & Chang-Soo Lee

Authors
  1. Reya Ganguly
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  2. Chang-Soo Lee
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Correspondence to Chang-Soo Lee .

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Editors and Affiliations

  1. Department of Engineering Design, Indian Institute of Technology Madras, Chennai, India

    Tuhin Subhra Santra

  2. Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan

    Fan-Gang Tseng

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Ganguly, R., Lee, CS. (2021). Microfluidic and Nanomaterial Approach for Virology. In: Santra, T.S., Tseng, FG. (eds) Handbook of Single Cell Technologies. Springer, Singapore. https://doi.org/10.1007/978-981-10-4857-9_46-1

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  • DOI: https://doi.org/10.1007/978-981-10-4857-9_46-1

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  • Print ISBN: 978-981-10-4857-9

  • Online ISBN: 978-981-10-4857-9

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