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Nucleophilic Fluorination of Electron-Deficient Arenes

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

(Hetero)aryl fluorides have found wide applications in pharmaceuticals, agrochemicals, and materials science, as well as in positron emission tomography (PET) [1,2,3,4]. Nucleophilic aromatic substitution of arenes with fluoride salts (SNAr fluorination) is one of the most convenient and economic methods to obtain (hetero)aryl fluorides [5, 6]. Electron-deficient arenes such as aryl chlorides and nitroarenes are the most commonly used substrates, which can readily undergo SNAr fluorination in the absence of transition-metal catalysts (Scheme 1) [7].

Scheme 1
scheme 1

Nucleophilic fluorination of electron-deficient (hetero)arenes

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Authors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Bo Xing, Chuanfa Ni & Jinbo Hu

Authors
  1. Bo Xing
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  2. Chuanfa Ni
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  3. Jinbo Hu
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Correspondence to Jinbo Hu .

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Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Xing, B., Ni, C., Hu, J. (2020). Nucleophilic Fluorination of Electron-Deficient Arenes. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_60-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_60-1

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  • Print ISBN: 978-981-10-1855-8

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