2,2-Difluoro-1,3-Dimethylimidazolidine (DFI) Deoxofluorination
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2,2-Difluoro-1,3-dimethylimidazolidine (DFI) was first reported as a novel deoxofluorination reagent by Hayashi and coworkers in 2002 . It is a clear liquid with boiling point of 47 °C at 37 mmHg and melting point of −8.7 °C . In terms of the chemical structure, DFI is similar to other α,α-difluoroalkylamine agents such as Yarovenko  and Ishikawa  agent. Accelerating rate calorimetry (ARC) analysis showed that thermal decomposition of DFI begins at 150 °C , while diethylaminosulfur trifluoride (DAST) decomposes at about 90 °C , indicating that DFI is much more thermally stable.
Deoxofluorination with DFI
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