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CpFluor Deoxofluorination

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

Fluorine is one of the vital organic chemistry elements, which can lead to significant variations in molecules’ chemical and physical properties. Thus, organofluorine compounds have been widely used in functional materials, medicinal science, life science, and many other fields [1,2,3,4]. In contrast to the abundance of inorganic fluorine-containing compounds, naturally occurring organofluorine compounds are scarce. Therefore, many efforts have been taken to develop fluorine-incorporation methods into organic molecules [5]. Among them, deoxofluorination of alcohols via nucleophilic fluorination is one of the major methods to acquire alkyl fluorides (Fig. 1). After SF4 was successfully applied in deoxofluorination in 1958 [7], many deoxofluorination reagents have been invented [5,6,7,8,9,10,11,12,13,14,15,16,17]. At present, the widely used reagents can be divided into three categories: 1) sulfur fluorides and their derivatives (SF reagents, Fig. 1a) [7,8,9,10,11]; 2)...

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Authors and Affiliations

  1. The Institute For Advanced Studies, Wuhan University, Wuhan, China

    Weilu Zhang & Xiao Shen

Authors
  1. Weilu Zhang
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  2. Xiao Shen
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Corresponding author

Correspondence to Xiao Shen .

Editor information

Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Zhang, W., Shen, X. (2018). CpFluor Deoxofluorination. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_44-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_44-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1855-8

  • Online ISBN: 978-981-10-1855-8

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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