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Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

Introduction

Positron emission tomography (PET) is a noninvasive medical imaging technique that has been rapidly developing in the past several decades. By imaging the uptake and distribution of a radiolabeled molecule, PET is an important diagnostic tool for investigating diverse types of diseases in preclinical and clinical research and drug development. Compared to other imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), X-ray, or ultrasound which provide structural and anatomical information, PET provides quantitative functional information about biological process at the molecular level. Following by in vivo injection of molecules labeled with positron-emitters, PET imaging is accomplished by the detection of two gamma ray photons (511 keV, ~180° apart) from annihilation of a positron (from β+-decay from radiolabeled molecules) and an electron in proximity. Frequently used positron-emitting radionuclides include carbon-11 (11C, half-life...

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Acknowledgement

S.H.L is a recipient of NIH career development award (DA038000) and Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM, DA043507) from the National Institute on Drug Abuse.

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Authors and Affiliations

  1. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Jian Rong & Steven H. Liang

Authors
  1. Jian Rong
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  2. Steven H. Liang
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Corresponding author

Correspondence to Steven H. Liang .

Editor information

Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Rong, J., Liang, S.H. (2018). Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_38-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_38-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1855-8

  • Online ISBN: 978-981-10-1855-8

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