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Nickel-Mediated Fluorination for Preparing Aryl Fluorides

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

Practical methods for aryl fluoride synthesis are of great interest for a number of applications. The limitations of the classical means of aryl fluoride synthesis, such as the Balz-Schiemann reaction and nucleophilic aromatic substitution, have stimulated a burst of research into the use of transition metals for aromatic fluorination [1,2,3,4]. Among the transition metals shown to be useful for aryl fluoride bond formation are copper, silver, palladium, and nickel. Of these, the fluorination reactivity of nickel is perhaps least advanced, especially in comparison to its group 10 cousin palladium (see chapter “Palladium-mediated Fluorination for Preparing Aryl Fluorides”). However, nickel-mediated aromatic fluorination has managed to find an application in the synthesis of 18F-labeled aryl fluoride PET tracers.

On top of the well-understood fundamental challenges involved in the preparation of aryl fluorides, the synthesis of 18F-labeled PET tracers lays additional...

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Authors and Affiliations

  1. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany

    Gregory B. Boursalian & Tobias Ritter

Authors
  1. Gregory B. Boursalian
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  2. Tobias Ritter
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Correspondence to Gregory B. Boursalian .

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Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Boursalian, G.B., Ritter, T. (2018). Nickel-Mediated Fluorination for Preparing Aryl Fluorides. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_35-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_35-1

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  • Print ISBN: 978-981-10-1855-8

  • Online ISBN: 978-981-10-1855-8

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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