Fluorination

Living Edition
| Editors: Jinbo Hu, Teruo Umemoto

Electrochemical Fluorination for Preparing Aryl Fluorides

  • Toshio FuchigamiEmail author
  • Shinsuke Inagi
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-1855-8_25-1

Introduction

Aryl fluorides including fluorinated heteroaromatic compounds are of much importance since they exhibit unique and pronounced biological activities. In fact, a number of partially fluorinated aryl compounds are currently used as pharmaceuticals and agrochemicals. Electrochemical partial fluorination of aromatic compounds has received much attention. Electrochemical fluorination of aryl compounds very often provides difluoro products as well as monofluoro products since monofluoro products have similar or a little lower oxidation potentials compared with starting aryl compounds. Furthermore, electrochemical fluorination of aryl compounds sometimes provides nonaromatic multifluorinated products. Therefore, electrochemical fluorination of aryl compounds is usually not so selective, and the yield is generally moderate to low [ 1, 2, 3, 4]. However, electrochemical partial fluorination can be carried out under safe conditions without any hazardous reagents. This is a big...
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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of ElectrochemistryTokyo Institute of TechnologyMidori-kuJapan