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Fluolead (Ar-SF3) Deoxofluorination

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

Fluorine has become a crucial element in medicinal chemistry, and nowadays, 20–25% of marked drugs are estimated to contain at least one fluorine atom in their structures. Introduction of fluorine into biologically active organic molecules significantly affects their lipophilicity, solubility, acidity, and basicity causing the modulation and/or improvement of their binding affinity, pharmacokinetic properties, and bioavailability [14, 24, 31, 39]. Therefore, numerous efforts have concentrated on the development of effective methods for fluorination reactions. Fluorinating reagents are one of the keys for the success of the transformation [1, 2, 5, 9, 11, 23, 25, 42, 43]. A variety of deoxofluorinating reagents have been developed for this purpose, which enable oxygen-containing compounds such as alcohols and carbonyls to be transformed into corresponding fluorides.

Deoxofluorinating reagents are divided into next categories: α-fluorinated alkylamines (NCF reagents) and...

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Authors and Affiliations

  1. Department of Nanopharmaceutical Sciences, Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, 466-8555, Gokiso, Showa-ku, Nagoya, Japan

    Benqiang Cui & Norio Shibata

Authors
  1. Benqiang Cui
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  2. Norio Shibata
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Correspondence to Norio Shibata .

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Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Cui, B., Shibata, N. (2018). Fluolead (Ar-SF3) Deoxofluorination. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_17-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_17-1

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  • Print ISBN: 978-981-10-1855-8

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