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Functionalization of Alkynes for Preparing Alkenyl Fluorides

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

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Introduction

Fluorine, called once a “small atom with a big ego,” has drawn much attentions from organic chemists due to its special properties [1, 2]. More specifically, nearly 25% of commercially pharmaceutical drugs and 40% of agrochemicals contain fluorine atoms [3,4,5]. Because quite few naturally occurring organofluoro compounds have been found, various strategies for introduction of fluorine into organic molecules have been developed since the last century [6,7,8,9,10,11]. Among numerous fluorine-containing compounds, monofluoroalkene is of particular importance because alkene is ubiquitous in bioactive molecules [12,13,14,15,16,17] and materials [18,19,20,21]. Moreover, fluoroalkenes could also serve as fluorinated building blocks for further organic transformations [22,23,24,25,26]. Therefore, this entry will focus on the preparation of mono- or difunctionalized alkenyl fluorides from readily available alkyne precursors.

Hydrofluorination of Alkyne to Prepare...

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Authors and Affiliations

  1. Department of Chemistry, University of Louisville, Louisville, KY, 40292, USA

    Shengzong Liang & Gerald B. Hammond

  2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China

    Bo Xu

Authors
  1. Shengzong Liang
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  2. Gerald B. Hammond
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  3. Bo Xu
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Corresponding authors

Correspondence to Gerald B. Hammond or Bo Xu .

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Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. R&D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd, Taizhou, Zhejiang, China

    Teruo Umemoto

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Liang, S., Hammond, G.B., Xu, B. (2018). Functionalization of Alkynes for Preparing Alkenyl Fluorides. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-1855-8_15-1

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  • DOI: https://doi.org/10.1007/978-981-10-1855-8_15-1

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  • Print ISBN: 978-981-10-1855-8

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