Fluorination

Living Edition
| Editors: Jinbo Hu, Teruo Umemoto

Functionalization of Alkynes for Preparing Alkenyl Fluorides

  • Shengzong Liang
  • Gerald B. HammondEmail author
  • Bo XuEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-1855-8_15-1

Introduction

Fluorine, called once a “small atom with a big ego,” has drawn much attentions from organic chemists due to its special properties [1, 2]. More specifically, nearly 25% of commercially pharmaceutical drugs and 40% of agrochemicals contain fluorine atoms [3, 4, 5]. Because quite few naturally occurring organofluoro compounds have been found, various strategies for introduction of fluorine into organic molecules have been developed since the last century [6, 7, 8, 9, 10, 11]. Among numerous fluorine-containing compounds, monofluoroalkene is of particular importance because alkene is ubiquitous in bioactive molecules [12, 13, 14, 15, 16, 17] and materials [18, 19, 20, 21]. Moreover, fluoroalkenes could also serve as fluorinated building blocks for further organic transformations [22, 23, 24, 25, 26]. Therefore, this entry will focus on the preparation of mono- or difunctionalized alkenyl fluorides from readily available alkyne precursors.

Hydrofluorination of Alkyne to...

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of LouisvilleLouisvilleUSA
  2. 2.College of Chemistry, Chemical Engineering and BiotechnologyDonghua UniversityShanghaiChina