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Oxidized (Phospho)lipids

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Encyclopedia of Lipidomics

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Definitions

Oxidized (Phospho)lipids – molecular species generated from (poly)unsaturated diacyl- and alk(en)ylacyl phospholipids via enzymatic and non-enzymatic oxidation.

Synonyms

Oxidized glycerophospholipids, oxPL (abbr)

Oxidized glycerophospholipids, previously seen mainly as a toxic byproduct of free radical reactions, nowadays are recognized as an important mediator of various cellular responses and play a significant role in organism redox balance. Early studies mainly focused on free fatty acid (FFA)-derived lipid peroxidation products (LPPs), especially iso- and neuroprostanes, established them as biomarkers of inflammatory pathways in mammals. Recently, structural and biological activity studies have been translated from FFA-derived LPPs to oxidized phospholipids (oxPLs). oxPLs have been shown to play a significant role in various and often controversial biological functions including pro- and anti-inflammatory pathways, cell death signaling, and pro-survival effects (Greiq...

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Abbreviations

12-LOX:

12-lipoxygenase

15-LOX:

15-lipoxygenase

COX:

Cyclooxygenase

DAG:

Diacylglycerols

FA:

Fatty acid

FFA:

Free fatty acid

HETEs:

Hydroxyeicosatetraenoic acids

HNE:

4-hydroxy-nonenal

LOX:

Lipoxygenases

LPPs:

Lipid peroxidation products

lysoPL:

Lysophospholipids

MDA:

Malondialdehyde

MPO:

Myeloperoxidase

OAP:

Oxygen addition products

OCP:

Oxidative cleavage products

oxPLs:

Oxidized phospholipids

PE:

Phosphatidylethanolamine

PL:

Phospholipids

PONPC:

1-palmitoyl-2-(9′-oxo-nonanoyl)-sn-glycero-3-phosphocholine

PS:

Phosphatidylserine

PUFA:

Polyunsaturated fatty acids

ROS:

Reactive oxygen species

References

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Author information

Authors and Affiliations

  1. Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Leipzig, Germany

    Zhixu Ni & Maria Fedorova

  2. Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany

    Zhixu Ni & Maria Fedorova

Authors
  1. Zhixu Ni
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  2. Maria Fedorova
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Corresponding author

Correspondence to Maria Fedorova .

Editor information

Editors and Affiliations

  1. Yong Loo Lin School of Medicine Centre for Life Sciences, Singapore, Singapore

    Markus R. Wenk

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Ni, Z., Fedorova, M. (2018). Oxidized (Phospho)lipids. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_183-1

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  • DOI: https://doi.org/10.1007/978-94-007-7864-1_183-1

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7864-1

  • Online ISBN: 978-94-007-7864-1

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