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1-Hydroxypyrene as a Biomarker for Environmental Health

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General Methods in Biomarker Research and their Applications

Abstract

This chapter reviews current knowledge and literature on urinary 1-hydroxypyrene (1-OHP) as a biomarker of environmental and occupational exposure to polycyclic aromatic hydrocarbons (PAHs) and potential applications of 1-OHP to prognosis for diseases or other health conditions. Intra- and interindividual variations in urinary 1-OHP, kinetics of metabolism and excretion of 1-OHP, and correlations between urinary 1-OHP and PAH concentrations were presented to address whether urinary 1-OHP can serve as a reliable biomarker of exposure to PAHs. The evidence of PAH-associated disease and health effects and 1-OHP associations in humans was summarized and discussed to determine potential applications of urinary 1-OHP for prognosis and as an indicator of diseases and health conditions associated with PAH exposure.

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References

  • Agudo A, Peluso M, Munnia A, et al. Aromatic DNA adducts and risk of gastrointestinal cancers: a case-cohort study within the EPIC-Spain. Cancer Epidemiol Biomarkers Prev. 2012;21:685–92.

    Article  CAS  PubMed  Google Scholar 

  • Alexandrie AK, Warholm M, Carstensen U, et al. CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. Carcinogenesis. 2000;21:669–76.

    Article  CAS  PubMed  Google Scholar 

  • Alshaarawy O, Zhu M, Ducatman A, et al. Polycyclic aromatic hydrocarbon biomarkers and serum markers of inflammation. A positive association that is more evident in men. Environ Res. 2013;126:98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Angerer J, Mannschreck C, Gündel J. Biological monitoring and biochemical effect monitoring of exposure to polycyclic aromatic hydrocarbons. Int Arch Occup Environ Health. 1997;70:365–77.

    Article  CAS  PubMed  Google Scholar 

  • Baarends WM, van der Laan R, Grootegoed JA. DNA repair mechanisms and gametogenesis. Reproduction. 2001;121:31–9.

    Article  CAS  PubMed  Google Scholar 

  • Boogaard PJ, van Sittert NJ. Exposure to polycyclic aromatic hydrocarbons in petrochemical industries by measurement of urinary 1-hydroxypyrene. Occup Environ Med. 1994;51:250–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bouchard M, Pinsonneault L, Tremblay C, et al. Biological monitoring of environmental exposure to polycyclic aromatic hydrocarbons in subjects living in the vicinity of a creosote impregnation plant. Int Arch Occup Environ Health. 2001;74:505–13.

    Article  CAS  PubMed  Google Scholar 

  • Brucker N, Moro AM, Charão MF, et al. Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers. Sci Total Environ. 2013;463–464:884–93.

    Article  PubMed  Google Scholar 

  • Buchet JP, Ferreira Jr M, Burrion JB, et al. Tumor markers in serum, polyamines and modified nucleosides in urine, and cytogenetic aberrations in lymphocytes of workers exposed to polycyclic aromatic hydrocarbons. Am J Ind Med. 1995;27(4):523–43.

    Article  CAS  PubMed  Google Scholar 

  • Burstyn I, Kromhout H, Partanen T, et al. Polycyclic aromatic hydrocarbons and fatal ischemic heart disease. Epidemiology. 2005;16:744–50.

    Article  PubMed  Google Scholar 

  • Chen B, Hu Y, Jin T, et al. The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007;381:38–46.

    Article  CAS  PubMed  Google Scholar 

  • Choi YH, Kim JH, Hong YC. CYP1A1 genetic polymorphism and polycyclic aromatic hydrocarbons on pulmonary function in the elderly: haplotype-based approach for gene-environment interaction. Toxicol Lett. 2013;221:185–90.

    Article  CAS  PubMed  Google Scholar 

  • Clark 3rd J, Serdar B, Lee DJ, et al. Exposure to polycyclic aromatic hydrocarbons and serum inflammatory markers of cardiovascular disease. Environ Res. 2012;117:132–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clonfero E, Granella M, Marchioro M, et al. Urinary excretion of mutagens in coke oven workers. Carcinogenesis. 1995;16(3):547–54.

    Article  CAS  PubMed  Google Scholar 

  • Crinnion WJ. The CDC, fourth national report on human exposure to environmental chemicals: what it tells us about our toxic burden and how it assists environmental medicine physicians. Altern Med Rev. 2010;15:101–9.

    PubMed  Google Scholar 

  • Curfs DMJ, Knaapen AM, Pachen DMFA, et al. Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. FASEB J. 2005;19:1290–2.

    CAS  PubMed  Google Scholar 

  • Dockery DW. Epidemiologic evidence of cardiovascular effects of particulate air pollution. Environ Health Perspect. 2001;109(4):483–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eom SY, Yim DH, Moon SI, et al. Polycyclic aromatic hydrocarbon-induced oxidative stress, antioxidant capacity, and the risk of lung cancer: a pilot nested case–control study. Anticancer Res. 2013;33:3089–97.

    CAS  PubMed  Google Scholar 

  • Epton MJ, Dawson RD, Brooks WM, et al. The effect of ambient air pollution on respiratory health of school children: a panel study. Environ Health. 2008;7:16.

    Article  PubMed  PubMed Central  Google Scholar 

  • Everett CJ, King DE, Player MS, et al. Association of urinary polycyclic aromatic hydrocarbons and serum C-reactive protein. Environ Res. 2010;110:79–82.

    Article  CAS  PubMed  Google Scholar 

  • Fagundes RB, Abnet CC, Strickland PT, et al. Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil. BMC Cancer. 2006;6:139.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferreira Jr M, Buchet JP, Burrion JB, et al. Determinants of urinary thioethers, d-glucaric acid and mutagenicity after exposure to polycyclic aromatic hydrocarbons assessed by air monitoring and measurement of 1-hydroxypyrene in urine: a cross-sectional study in workers of coke and graphite-electrode-producing plants. Int Arch Occup Environ Health. 1994;65:329–38.

    Article  CAS  PubMed  Google Scholar 

  • Grimmer G, Dettbarn G, Jacob J. Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols). Int Arch Occup Environ Health. 1993;65:189–99.

    Article  CAS  PubMed  Google Scholar 

  • Han Y, Xia Y, Zhu P, et al. Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males. Sci Total Environ. 2010a;408:768–73.

    Article  CAS  PubMed  Google Scholar 

  • Han X, Zhou N, Cui Z, et al. Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage: a population study in Chongqing, China. Environ Health Perspect. 2010b;119:652–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Han X, Zhou N, Cui Z, et al. Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage: a population study in Chongqing, China. Environ Health Perspect. 2011;119:652–7.

    Article  CAS  PubMed  Google Scholar 

  • Heikkilä PR, Luotamo M, Riihimaki V. Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility. Scand J Work Environ Health. 1997;23:199–205.

    Article  PubMed  Google Scholar 

  • Hemminki K, Dickey C, Karlsson S, et al. Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis. 1997;18:345–50.

    Article  CAS  PubMed  Google Scholar 

  • Hofmann JN, Liao LM, Strickland PT, Shu XO, Yang G, Ji BT, Li HL, Rothman N, Kamangar F, Gao YT, Zheng W, Chow WH. Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study. BMC Cancer. 2013;13:282.

    Google Scholar 

  • Huang H, Lai C, Chen G, et al. Traffic-related air pollution and DNA damage: a longitudinal study in Taiwanese traffic conductors. PLoS One. 2012;7:e37412.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • IARC. Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Lyon: IARC; 1983.

    Google Scholar 

  • Jeng HA, Pan CH, Diawara N, et al. Polycyclic aromatic hydrocarbons-induced oxidative stress and lipid peroxidation in relation to immunological alteration. Occup Environ Med. 2011;68(9):653–8.

    Article  CAS  PubMed  Google Scholar 

  • Jeng HA, Pan CH, Chao MR. 1-Hydroxypyrene as a biomarker for assessing the effects of exposure to polycyclic aromatic hydrocarbons on semen quality and sperm DNA integrity. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013a;48:152–8.

    Article  CAS  PubMed  Google Scholar 

  • Jeng HA, Pan CH, Lin WY, et al. Biomonitoring of polycyclic aromatic hydrocarbons from coke oven emissions and reproductive toxicity in nonsmoking workers. J Hazard Mater. 2013b;244–245:436–43.

    Article  PubMed  Google Scholar 

  • Ji G, Gu A, Zhu P, et al. Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility. Toxicol Sci. 2010;116(1):92–8.

    Article  CAS  PubMed  Google Scholar 

  • Jongeneelen FJ. Biological exposure limit for occupational exposure to coal tar pitch volatiles at cokeovens. Int Arch Occup Environ Health. 1992;63:511–6.

    Article  CAS  PubMed  Google Scholar 

  • Jongeneelen FJ, Anzion RBM, Scheepers PTJ, et al. 1-Hydroxypyrene in urine as a biological indicator of exposure to polycyclic aromatic hydrocarbons in several work environments. Ann Occup Hyg. 1988;32:35–43.

    Article  CAS  PubMed  Google Scholar 

  • Jongeneelen FJ, Van Leeuwen FE, Oosterink S, et al. Ambient and biological monitoring of cokeoven workers: determinants of the internal dose of polycyclic aromatic hydrocarbons. Br J Ind Med. 1990;47:454–61.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kasai H, Crain PF, Kuchino Y, et al. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 1986;7:1849–51.

    Article  CAS  PubMed  Google Scholar 

  • Kim JH, Stansbury KH, Walker NJ, et al. Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis. 1998;19:1847–53.

    Article  CAS  PubMed  Google Scholar 

  • Kim H, Cho SH, Kang JW, et al. Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans. Int Arch Occup Environ Health. 2001;74:59–62.

    Article  CAS  PubMed  Google Scholar 

  • Kim YD, Lee CH, Nan HM, Kang JW, Kim H. Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. J Occup Health. 2003;45(3):160–7.

    Google Scholar 

  • Kuljukka T, Vaaranrinta R, Veidebaum T, et al. Exposure to PAH compounds among cokery workers in the oil shale industry. Environ Health Perspect. 1996;3:539–41.

    Article  Google Scholar 

  • Launen LA, Pinto LJ, Percival PW, et al. Pyrene is metabolized to bound residues by Penicillium Janthinellum SFU403. Biodegradation. 2000;11:305–12.

    Article  CAS  PubMed  Google Scholar 

  • Lee J, Kang D, Lee KH, et al. Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers. Mutat Res. 2002;514:213–21.

    Article  CAS  PubMed  Google Scholar 

  • Lee KH, Shu XO, Gao YT, et al. Breast cancer and urinary biomarkers of polycyclic aromatic hydrocarbon and oxidative stress in the Shanghai Women’s Health Study. Cancer Epidemiol Biomarkers Prev. 2010;19:877–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee MS, Magari S, Christiani DC. Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med. 2011;68:474–8.

    Article  CAS  PubMed  Google Scholar 

  • Leem JH, Kim JH, Lee KH, et al. Asthma attack associated with oxidative stress by exposure to ETS and PAH. J Asthma. 2005;42:463–7.

    Article  CAS  PubMed  Google Scholar 

  • Levin JO. First international workshop on hydroxypyrene as a biomarker for PAH exposure in man summary and conclusions. Sci Total Environ. 1995;163:165–8.

    Article  CAS  Google Scholar 

  • Leroyer A, Jeandel F, Maitre A, Howsam M, Deplanque D, Mazzuca M, Nisse C. 1-Hydroxypyrene and 3-hydroxybenzo[a]pyrene as biomarkers of exposure to PAH in various environmental exposure situations. Sci Total Environ. 2010;408(5):1166–73.

    Google Scholar 

  • Li Z, Sandau DC, Romanoff CL, et al. Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population. Environ Res. 2008;107:320–31.

    Article  CAS  PubMed  Google Scholar 

  • Lin YC, Pan CH, Chen CJ, et al. Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwanese coke-oven workers. J Occup Environ Med. 2006;48(9):930–6.

    Article  CAS  PubMed  Google Scholar 

  • Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol Med. 1996;74:297–312.

    Article  CAS  PubMed  Google Scholar 

  • McClean M, Rinehart R, Ngo L, et al. Inhalation and dermal exposure among asphalt paving workers. Ann Occup Hyg. 2004;48(8):663–71.

    Article  CAS  PubMed  Google Scholar 

  • Merlo F, Andreassen A, Weston A. Urinary excretion of 1-hydroxypyrene as a marker for exposure to urban air levels of polycyclic aromatic hydrocarbons. Cancer Epidemiol Biomarkers Prev. 1998;7:147–55.

    CAS  PubMed  Google Scholar 

  • Mielzynska-Svach D, Blaszczyk E, Butkiewicz D, et al. Influence of genetic polymorphisms on biomarkers of exposure and effects in children living in Upper Silesia. Mutagenesis. 2013;28:591–9.

    Article  CAS  PubMed  Google Scholar 

  • Nelson DR, Koymans L, Kamataki T, et al. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 1996;6:1–42.

    Article  CAS  PubMed  Google Scholar 

  • Olsen AK, Andreassen A, Singh R, et al. Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis. PLoS One. 2010;5:e11349.

    Article  PubMed  PubMed Central  Google Scholar 

  • Orjuela MA, Liu X, Warburton D, et al. Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood. Mutat Res. 2010;703:108–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pan CH, Chan CC, Wu KY. Effects on Chinese restaurant workers of exposure to cooking oil fumes: a cautionary note on urinary 8-hydroxy-2′-deoxyguanosine. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3351–7.

    Google Scholar 

  • Peel JL, Metzger KB, Klein M, et al. Ambient air pollution and cardiovascular emergency department visits in potentially sensitive groups. Am J Epidemiol. 2007;165:625–33.

    Article  PubMed  Google Scholar 

  • Penn A, Snyder C. Arteriosclerotic plaque development is ‘promoted’ by polynuclear aromatic hydrocarbons. Carcinogenesis. 1988;9:2185–9.

    Article  CAS  PubMed  Google Scholar 

  • Petchpoung K, Kaojarern S, Yoovathaworn K, et al. The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers. Environ Toxicol Pharmacol. 2011;31:160–4.

    Article  CAS  PubMed  Google Scholar 

  • Peters S, Talaska G, Jönsson BA, et al. Polycyclic aromatic hydrocarbon exposure, urinary mutagenicity, and DNA adducts in rubber manufacturing workers. Cancer Epidemiol Biomarkers Prev. 2008;17:1452–9.

    Article  CAS  PubMed  Google Scholar 

  • Prado GF, Zanetta DM, Arbex MA, et al. Burnt sugarcane harvesting: particulate matter exposure and the effects on lung function, oxidative stress, and urinary 1-hydroxypyrene. Sci Total Environ. 2012;437:200–8.

    Article  CAS  PubMed  Google Scholar 

  • Pruul R, Kahn H, Kahru A. Application of the Ames genotoxicity assay and the bioluminescent toxicity assay in the testing of urine samples. Altern Lab Anim. 1993;21:225–32.

    Google Scholar 

  • Ramesh A, Walker SA, Hood DB, et al. Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. Int J Toxicol. 2004;23:301–33.

    Article  CAS  PubMed  Google Scholar 

  • Sánchez-Guerra M, Pelallo-Martínez N, Díaz-Barriga F, et al. Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children. Mutat Res. 2012;742:66–71.

    Article  PubMed  Google Scholar 

  • Sellappa S, Mani B, Keyan KS. Cytogenetic biomonitoring of road paving workers occupationally exposed to polycyclic aromatic hydrocarbons. Asian Pac J Cancer Prev. 2011;12:713–7.

    PubMed  Google Scholar 

  • Å imko P. Factors affecting elimination of polycyclic aromatic hydrocarbons from smoked meat foods and liquid smoke flavorings. Mol Nutr Food Res. 2005;49:637–47.

    Article  PubMed  Google Scholar 

  • Strickland P, Kang D, Sithisarankul P. Polycyclic aromatic hydrocarbon metabolites in urine as biomarkers of exposure and effect. Environ Health Perspect. 1996;104:927–932.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tas S, Buchet JP, Lauwerys R. Determinants of benzo(a)pyrene diol epoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons. Int Arch Occup Environ Health. 1994;66:343–8.

    Article  CAS  PubMed  Google Scholar 

  • Tolos WP, Shaw PB, Lowry LK, MacKenzie BA, Deng J, Markel HL. 1-phrenol: a biomarker for occupational exposure to polycyclic aromatic hydcarbons. Appl Environ Hyg. 1990;5:303–309.

    Google Scholar 

  • Tuchsen F, Andersen O, Costa G, et al. Occupation and ischemic heart disease in the European Community: a comparative study of occupations at potential high risk. Am J Ind Med. 1996;30:407–14.

    Article  CAS  PubMed  Google Scholar 

  • Van Schooten FJ, Jongeneelen FJ, Hillebrand MJX, et al. Polycyclic aromatic hydrocarbon–DNA adducts in white blood cell DNA and 1-hydroxypyrene in the urine from aluminum workers: relation with job category and synergistic effect of smoking. Cancer Epidemiol Biomarkers Prev. 1995;4:69–77.

    PubMed  Google Scholar 

  • Vanhummelen P, Gennart JP, Buchet JP, et al. Biological markers in PAH exposed workers and controls. Mutat Res. 1993;300:231–9.

    Article  CAS  Google Scholar 

  • Walker B, Mouton Jr CP, Walker Jr B, et al. Environmental influences on cardiovascular health. J Natl Med Assoc. 2008;100:98–102.

    Article  PubMed  Google Scholar 

  • Ward DJ, Ayres JG. Particulate air pollution and panel studies in children: a systematic review. Occup Environ Med. 2004;61:e13. doi:10.1136/oem.2003.007088.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • WHO (World Health Organization). Polycyclic aromatic hydrocarbons: 1-Hydroxypyrene in urine. In: Biological monitoring of chemical exposure in the workplace, guidelines, vol. 2. Geneva: WHO; 1996.

    Google Scholar 

  • Wu MT, Simpson CD, Christiani DC, et al. Relationship of exposure to coke-oven emissions and urinary metabolites of benzo(a)pyrene and pyrene in coke-oven workers. Cancer Epidemiol Biomarkers Prev. 2002;11(3):311–4.

    CAS  PubMed  Google Scholar 

  • Wu MT, Pan CH, Wu TN, et al. Immunological finings in a group of coke-oven workers exposed to polycyclic aromatic hydrocarbons. J Occup Environ Med. 2003;45:1034–9.

    Article  CAS  PubMed  Google Scholar 

  • Wu LL, Chiou CC, Chang PY, et al. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta. 2004;339:1–9.

    Article  CAS  PubMed  Google Scholar 

  • Wu J, Hou H, Ritz B, et al. Exposure to polycyclic aromatic hydrocarbons and missed abortion in early pregnancy in a Chinese population. Sci Total Environ. 2010;408:2312–8.

    Article  CAS  PubMed  Google Scholar 

  • Xia Y, Han Y, Zhu P, et al. Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality. Environ Sci Technol. 2009;43:4567–73.

    Article  CAS  PubMed  Google Scholar 

  • Yamano Y, Hara K, Ichiba M, et al. Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China. Int Arch Occup Environ Health. 2014;87(7):705–13.

    Google Scholar 

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Authors and Affiliations

  1. School of Community and Environmental Health, College of Health Sciences, Old Dominion University, 4608 Hampton Boulevard Health Sciences Building 3140, Virginia, VA, 23508, USA

    Hueiwang Anna Jeng

  2. Division of Occupational Hazards Assessment, Institute of Labor, Occupational Safety and Health, Ministry of Labor, Taipei County 221, Taiwan

    Chin-Hong Pan

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  1. Hueiwang Anna Jeng
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Correspondence to Hueiwang Anna Jeng .

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Editors and Affiliations

  1. Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom

    Victor R. Preedy

  2. Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Jeng, H.A., Pan, CH. (2015). 1-Hydroxypyrene as a Biomarker for Environmental Health. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7696-8_49

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