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Biomarkers of Necrosis and Myocardial Remodeling

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General Methods in Biomarker Research and their Applications

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Abstract

Multiple biomarkers have helped us to understand the pathophysiology of cardiovascular medicine, being ischemic heart disease and heart failure the most active fields in which biomarkers have shown to be useful. Furthermore, in several cardiovascular diseases, as heart failure, hypertrophic or dilated cardiomyopathies have demonstrated the presence of remodeling in both ventricles, with mainly changes in the extracellular matrix. The initial post-MI phase of left ventricular remodeling is resulted from a fibrotic repair of the necrotic area with scar formation, elongation, and thinning of the infarcted zone.

This book chapter summarizes a review about biomarkers of necrosis and myocardial remodeling and all the knowledge that their study has improved the complex role of this cardiac pathology. The continued research of new molecules that helped us to understand necrosis and remodeling focuses our attention in different groups of biomarkers as troponins, growth factors, matrix metalloproteinases, and collagen peptides. This chapter is also focused on how the renin-angiotensin system influences the cardiac remodeling and the role of microRNAs in extracellular changes.

Funding: This work was partially supported by Sociedad Española de Cardiología, RD06/0014/039, (RECAVA) from ISCIII, Beca Cajamurcia-FFIS 2010, and PI081531-FEDER from ISCIII.

Competing interests: None declared in relation to this manuscript for all authors. JAV and DHR have received funding for research from Abbott. MV has received funding for research and consultancy from Abbott and Boston Scientific. FM has received funding for research, consultancy, and lecturing from Abbott, Boston Scientific, Bayer, AstraZeneca, Daiichi-Sankyo, BMS/Pfizer, and Boehringer Ingelheim.

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Acknowledgments

JA Vílchez holds a research grant “Río Hortega” by the Instituto de Salud Carlos III, Madrid, Spain.

Dr. Orenes-Piñero is supported by a postdoctoral contract from Fundación para la Formación e Investigación Sanitarias de la Región de Murcia, Murcia, Spain.

D Hernandez-Romero holds a research grant “Sara Borrell” by the Instituto de Salud Carlos III, Madrid, Spain.

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Authors and Affiliations

  1. Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, University of Murcia, Ctra Madrid-Cartagena s/n, 30120, Murcia, Spain

    Juan Antonio Vílchez, Esteban Orenes-Piñero, Diana Hernández-Romero, Mariano Valdés & Francisco Marín

  2. Department of Clinical Analysis, Hospital Universitario Virgen de la Arrixaca, University of Murcia, Ctra Madrid-Cartagena s/n, 30120, Murcia, Spain

    Juan Antonio Vílchez

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  1. Juan Antonio Vílchez
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  2. Esteban Orenes-Piñero
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Correspondence to Francisco Marín .

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Editors and Affiliations

  1. Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom

    Victor R. Preedy

  2. Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Vílchez, J.A., Orenes-Piñero, E., Hernández-Romero, D., Valdés, M., Marín, F. (2015). Biomarkers of Necrosis and Myocardial Remodeling. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7696-8_42

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