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General Methods in Biomarker Research and their Applications pp 439–454Cite as

FABP3 as Biomarker of Heart Pathology

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Abstract

A complete understanding of the mechanisms leading to release of a protein used as a biomarker is fundamental for improving decisions on which biomarker to use for which specific pathology and how to combine biomarkers to aid the clinical assessment of patients. With the discovery of new regulatory machinery – such as posttranslational inhibition of mRNAs by microRNAs – previous knowledge must be updated and modified. The potential use of fatty-acid-binding protein 3 (FABP3) in evaluating cardiovascular pathologies is no exception in this regard. FABP3 is a small protein that is abundantly expressed in the cytoplasm of cardiomyocytes and that has been proposed as an early biomarker of myocardial injury. We highlight here new findings on the mechanisms leading to secretion of FABP3 and specifically how a striated muscle-specific microRNA, namely, miR-1, regulates the expression of FABP3 in different cardiac pathologies.

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Abbreviations

AMI:

Acute Myocardial Infarction

AS:

Aortic Stenosis

cTn:

Cardiac Troponin

FABP3:

Fatty-Acid-Binding Protein 3

GH:

Growth Hormone

HEK 293:

Human Embryonic Kidney 293 Cell Line

IGF1:

Insulin-Like Growth Factor 1

miRNA/miR:

microRNA

PCR:

Polymerase Chain Reaction

PPAR:

Peroxisome Proliferator-Activated Receptor

RISC:

RNA-Induced Silencing Complex

TAC:

Transverse Aortic Constriction

UTR:

Untranslated Region

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Authors and Affiliations

  1. National Research Council (CNR) Institute of Genetic and Biomedical Research (IRGB) - UOS of Milan, Humanitas Clinical and Research Center, Via Manzoni 113, Rozzano, MI, 20089, Italy

    Daniele Catalucci & Gianluigi Condorelli

  2. Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, MI, 20089, Italy

    Michael V. G. Latronico

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  1. Daniele Catalucci
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  2. Michael V. G. Latronico
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  3. Gianluigi Condorelli
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Correspondence to Gianluigi Condorelli .

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Editors and Affiliations

  1. Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom

    Victor R. Preedy

  2. Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Catalucci, D., Latronico, M.V.G., Condorelli, G. (2015). FABP3 as Biomarker of Heart Pathology. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7696-8_22

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