Skip to main content
SpringerLink
Log in

Chronic Heart Failure and Serum Collagen

  • Reference work entry
  • First Online:
General Methods in Biomarker Research and their Applications

Abstract

Heart failure is a highly complex clinical syndrome which involves structural, hormonal, and molecular changes. In heart failure, turnover of the extracellular matrix is the main factor determining cardiac remodeling. The fibrillar interstitial types I and III collagens are the major structural components of the cardiac extracellular matrix. Serum collagen-derived peptides have been proposed as promising early indicators of cardiac remodeling and as useful tools to evaluate myocardial fibrosis noninvasively. Consequently, the assessment of such biomarkers could provide insight into disease progression and risk stratification of chronic heart failure syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 399.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ACEi:

Angiotensin-Converting Enzyme Inhibitor

ARB:

Angiotensin Receptor Blocker

BNP:

Brain Natriuretic Peptide

CHF:

Chronic Heart Failure

CITP:

Carboxy-Terminal Telopeptide of Collagen Type I

DHF:

Diastolic Heart Failure

ECM:

Extracellular Matrix

HFPSF:

Heart Failure with Preserved Systolic Function

ICD:

Implantable Cardioverter-Defibrillator

IL:

Interleukin

LV:

Left Ventricle

MMPs:

Matrix Metalloproteinases

NT-proBNP:

Amino-terminal Propeptide of Brain Natriuretic Peptide

NYHA:

New York Heart Association

PICP:

Carboxy-terminal Propeptide of Procollagen Type I

PIIICP:

Carboxy-terminal Propeptide of Procollagen Type III

PIIINP:

Amino-terminal Propeptide of Procollagen Type III

PINP:

Amino-terminal Propeptide of Procollagen Type I

SHF:

Systolic Heart Failure

TGF-β:

Transforming Growth Factor Beta

TIMPs:

Tissue Inhibitors of Metalloproteinases

References

  • Abulhul E, McDonald K, Martos R, et al. Long-term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B-type natriuretic peptide. Clin Ther. 2012;34:91–100.

    Article  CAS  PubMed  Google Scholar 

  • Alberts B, Johnson A, Lewis J, et al. Molecular biology of the cell. 4th ed. New York: Garland Science; 2002. p. 1096–101.

    Google Scholar 

  • Assayag P, Carre F, Chevalier B, et al. Compensated cardiac hypertrophy. Arrhythmogenecity and the new myocardial phenotype. Part 1: fibrosis. Cardiovasc Res. 1997;34:439–44.

    Article  CAS  PubMed  Google Scholar 

  • Badenhorst D, Maseko M, Tsotetsi OJ, et al. Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats. Cardiovasc Res. 2002;57:632–41.

    Article  Google Scholar 

  • Baramova E, Foidart JM. Matrix metalloproteinase family. Cell Biol Int. 1995;19:239–42.

    CAS  PubMed  Google Scholar 

  • Berger R, Huelsman M, Strecker K, et al. B- type natriuretic peptide predicts sudden death in patients with chronic heart failure. Circulation. 2002;105:2392–7.

    Article  PubMed  Google Scholar 

  • Blangy H, Sadoul N, Dousset B, et al. Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction. Europace. 2007;9:724–9.

    Article  PubMed  Google Scholar 

  • Bonapace S, Rossi A, Cicoira M, et al. Aortic stiffness correlates with an increased extracellular matrix turnover in patients with dilated cardiomyopathy. Am Heart J. 2006;152:93.e1–e6.

    Article  Google Scholar 

  • Bosman FT, Stamenkovic I. Functional structure and composition of the extracellular matrix. J Pathol. 2003;200:423–8.

    Article  CAS  PubMed  Google Scholar 

  • Burlew BS, Weber KT. Connective tissue and the heart: functional significance and regulatory mechanisms. Cardiol Clin. 2000;18:435–42.

    Article  CAS  PubMed  Google Scholar 

  • Caulfield JB, Borg TK. The collagen network of the heart. Lab Invest. 1999;40:364–72.

    Google Scholar 

  • Chatzikyriakou S, Tziakas D, Chalikias G, et al. Serum levels of collagen type I degradation markers are associated with vascular stiffness in chronic heart failure patients. Eur J Heart Fail. 2008;10:1181–5.

    Article  CAS  PubMed  Google Scholar 

  • Chatzikyriakou S, Tziakas D, Chalikias G, et al. Resolution of symptoms and serum peptides of collagen type I turnover in acute heart failure patients. Acta Cardiol. 2009;64:29–33.

    Article  PubMed  Google Scholar 

  • Chatzikyriakou S, Tziakas D, Chalikias G, et al. Chronic heart failure patients with high collagen type I degradation marker levels benefit more with ACE-inhibitor therapy. Eur J Pharmacol. 2010;25:164–70.

    Article  Google Scholar 

  • Chatzikyriakou S, Tziakas D, Chalikias G, et al. Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure. Qual Life Res. 2012;21:143–53.

    Article  PubMed  Google Scholar 

  • Cicoira M, Rossi A, Bonapace S, et al. Independent and additional prognostic value of aminoterminal propeptide of type III procollagen circulating levels in patients with chronic heart failure. J Card Fail. 2004;10:403–11.

    Article  CAS  PubMed  Google Scholar 

  • Cleutjens JP. The role of matrix metalloproteinases in heart disease. Cardiovasc Res. 1996;32:816–21.

    Article  CAS  PubMed  Google Scholar 

  • Deswal A, Richardson P, Bozkurt B, et al. Results of the Randomized Aldosterone Antagonism in heart failure with Preserved Ejection Fraction Trial (RAAM-PEF). J Card Fail. 2011;17:634–42.

    Article  PubMed  Google Scholar 

  • Goldsmith EC, Borg TK. The dynamic interaction of the extracellular matrix in cardiac remodelling. J Card Fail. 2002;8:S314–8.

    Article  CAS  PubMed  Google Scholar 

  • Guarda E, Katwa LC, Myers PR, et al. Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc Res. 1993;27:2130–4.

    Article  CAS  PubMed  Google Scholar 

  • Gunasighe SK, Spinale FG. Myocardial basis for heart failure: role of cardiac interstitium. In: Mann DL, editor. Heart failure: a companion to Braunwald’s heart disease: a textbook of cardiovascular medicine. Philadelphia: WB Saunders; 2004. p. 57–70.

    Google Scholar 

  • Heeneman S, Cleutjens JP, Faber BC, et al. The dynamic extracellular matrix: interventions strategies during heart failure and atherosclerosis. J Pathol. 2003;200:516–25.

    Article  CAS  PubMed  Google Scholar 

  • Hill R, Harper E. Quantitation of types I and III collagens in human tissue samples and cell culture by cyanogen bromide peptide analysis. Anal Biochem. 1984;141:83–93.

    Article  CAS  PubMed  Google Scholar 

  • Iraqi W, Rossignol P, Angioi M, et al. Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure. Insights from the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) Study. Circulation. 2009;119:2471–9.

    Article  CAS  PubMed  Google Scholar 

  • Jensen LT, Host NB. Collagen: scaffold for repair or execution. Cardiovasc Res. 1997;33:535–9.

    Article  CAS  PubMed  Google Scholar 

  • Jourdain P, Jondeau G, Funck F, et al. Plasma brain natriuretic peptide- guided therapy to improve outcome in heart failure. The STARS-BNP multicenter study. J Am Coll Cardiol. 2007;49:1733–9.

    Article  CAS  PubMed  Google Scholar 

  • Kanoupakis E, Manios E, Kallergis E, et al. Serum markers of collagen turnover predict future shocks in implantable cardioverter-defibrillator recipients with dilated cardiomyopathy on optimal treatment. J Am Coll Cardiol. 2010;55:2753–9.

    Article  CAS  PubMed  Google Scholar 

  • Kim HE, Dalal SS, Young E, et al. Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. J Clin Invest. 2000;106:857–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kitahara T, Takeishi Y, Arimoto T, Niizeki T, Koyama Y, Sasaki T, Suzuki S, Nozaki N, Hirono O, Nitobe J, Watanabe T, Kubota I. Serum carboxy-terminal telopeptide of type I collagen (ICTP) predicts cardiac events in chronic heart failure patients with preserved left ventricular systolic function.Circ J 2007;71:929–35.

    Google Scholar 

  • Klappacher G, Franzen P, Haab D, et al. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol. 1995;75:913–8.

    Article  CAS  PubMed  Google Scholar 

  • Koglin J, Pehlivanli S, Schwaiblmair M, et al. Role of brain natriuretic peptide in risk stratification of patient with congestive heart failure. J Am Coll Cardiol. 2001;38:1934–41.

    Article  CAS  PubMed  Google Scholar 

  • Krum H, Elsik M, Schneider H, et al. Relation of peripheral collagen markers to death and hospitalization in patients with heart failure and preserved ejection fraction. Results of the I-PRESERVE collagen substudy. Circ Heart Fail. 2011;4:561–8.

    Article  CAS  PubMed  Google Scholar 

  • Kunishige M, Kijima Y, Sakai T, et al. Transient enhancement of oxidant stress and collagen turnover in patients with acute worsening of congestive heart failure. Circ J. 2007;71:1893–7.

    Article  PubMed  Google Scholar 

  • Latini R, Mason S, Anand I, et al. Valsartan Heart Failure Trial Investigators: effects of valsartan on circulating brain natriuretic peptide and norepinephrine in symptomatic heart failure: the Valsartan Heart Failure Trial (Val-HeFT). Circulation. 2002;106:2454–8.

    Article  CAS  PubMed  Google Scholar 

  • Li YY, McTiernan CF, Feldman AM. Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodelling. Cardiovasc Res. 2000;46:214–24.

    Article  CAS  PubMed  Google Scholar 

  • Lihnen PJ, Petrov VV, Fagerd RH. Induction of cardiac fibrosis by transforming growth factor beta 1. Mol Genet Metab. 2000;71:418–35.

    Article  Google Scholar 

  • Lompardi R, Betocchi S, Losi MA, et al. Myocardial collagen turnover in hypertrophic cardiomyopathy. Circulation. 2003;108:1455.

    Article  Google Scholar 

  • Lopez B, Quejereta R, Varo N, et al. Usefulness of serum carboxy-terminal propeptide of procollagen type I to assess the cardioreparative ability of antihypertensive treatment in hypertensive patients. Circulation. 2001;104:286–91.

    Article  CAS  PubMed  Google Scholar 

  • Lopez B, Quejereta R, Gonzalez A, et al. Effect of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure. J Am Coll Cardiol. 2004;43:2028–35.

    Article  CAS  PubMed  Google Scholar 

  • Lopez B, Gonzalez A, Quejereta R, et al. The use of collagen derived serum peptides for the clinical assessment of hypertensive heart disease. J Hypertens. 2005;23:1445–51.

    Article  CAS  PubMed  Google Scholar 

  • Lopez B, Gonzalez A, Querejeta R, et al. Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure. J Am Coll Cardiol. 2006;48:89–96.

    Article  CAS  PubMed  Google Scholar 

  • Mak GJ, Ledwidge MT, Watson CJ, Phelan DM, et al. Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone. J Am Coll Cardiol. 2009;54:1674–82.

    Article  CAS  PubMed  Google Scholar 

  • Martos R, Baugh J, Ledwidge M, et al. Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation. 2007;115:888–95.

    Article  PubMed  Google Scholar 

  • McCullagh K, Duance V, Bishop K. The distribution of collagen types I, III and V (AB) in normal and atherosclerotic human aorta. J Pathol. 1980;130:45–55.

    Article  CAS  PubMed  Google Scholar 

  • Murphy G, Willenbrock F, Crabbe T, et al. Regulation of matrix metalloproteinase activity. Ann N Y Acad Sci. 1994;732:31–41.

    Article  CAS  PubMed  Google Scholar 

  • Nimmi ME. Fibrillar collagens: their biosynthesis, molecular structure and mode of assembly. In: Zern MA, Reid LM, editors. Extracellular matrix. New York: Marcel Decker; 1993. p. 121–48.

    Google Scholar 

  • Opie LH. The neuroendocrinology of congestive heart failure. Cardiovasc J South Afr. 2002;13:171–8.

    Google Scholar 

  • Quejereta R, Lopez B, Gonzalez A, et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin. Circulation. 2004;110:1263–8.

    Article  Google Scholar 

  • Radauceanu A, Ducki C, Virion JM, et al. Extracellular matrix turnover and inflammatory markers independently predict functional status and outcome in chronic heart failure. J Card Fail. 2008;14:467–74.

    Article  CAS  PubMed  Google Scholar 

  • Richards M, Troughton RW. NT-proBNP in heart failure: therapy decisions and monitoring. Eur J Heart Fail. 2004;6:351–4.

    Article  CAS  PubMed  Google Scholar 

  • Risteli L, Risteli J. Noninvasive methods for detection of organ fibrosis. In: Rojkind M, editor. Connective tissue in health and disease. Boca Raton: CRC Press; 1990. p. 61–98.

    Google Scholar 

  • Rossi A, Cicoira M, Golia G, et al. Amino- terminal propeptide of type III procollagen is associated with restrictive mitral filling pattern in patients with dilated cardiomyopathy: a possible link between diastolic dysfunction and prognosis. Heart. 2004;90:650–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schwartzkopff B, Fassbach M, Pelzer B, et al. Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy. Eur J Heart Fail. 2002;4:439–44.

    Article  CAS  PubMed  Google Scholar 

  • Sil P, Sen S. Angiotensin II and myocyte growth: role of fibroblasts. Hypertension. 1997;30:209–16.

    Article  CAS  PubMed  Google Scholar 

  • Silver M, Pick R, Brilla CG, et al. Reactive and reparative fibrillar collagen remodelling in the hypertrophied rat left ventricle: two experimental models of myocardial fibrosis. Cardiovasc Res. 1990;24:741–7.

    Article  CAS  PubMed  Google Scholar 

  • Streuli C. Extracellular matrix remodelling and cellular differentiation. Curr Opin Cell Biol. 1999;11:634–40.

    Article  CAS  PubMed  Google Scholar 

  • Swynghedauw B. Molecular mechanisms of myocardial remodelling. Physiol Rev. 1999;79:215–62.

    CAS  PubMed  Google Scholar 

  • Timonen P, Magga J, Risteli J, et al. Cytokines, interstitial collagen and ventricular remodelling in dilated cardiomyopathy. Int J Cardiol. 2008;124:293–300.

    Article  PubMed  Google Scholar 

  • Tsutamoto T, Wada A, Maeda K, et al. Effect of spironolactone on plasma brain natriuretic peptide in patients with congestive heart failure. J Am Coll Cardiol. 2001;37:1228–33.

    Article  CAS  PubMed  Google Scholar 

  • Tziakas D, Chalikias G, Stakos D, et al. Independent and additive prognostic ability of serum carboxy-terminal telopeptide of collagen type-I in heart failure patients: a multi-marker approach with high-negative predictive value to rule out long-term adverse events. Eur J Prev Cardiol. 2012;19:62–71.

    Article  PubMed  Google Scholar 

  • Weber KT, Sun Y, Tyagi SC, Cleutjens JP. Collagen network of the myocardium: function, structural remodelling and regulatory mechanisms. J Mol Cell Cardiol. 1994;26:279–92.

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto K, Mano T, Yoshiba J, et al. ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. J Hypertens. 2005;23:393–400.

    Article  CAS  PubMed  Google Scholar 

  • Zannad F, Alla F, Dousset B, et al. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure. Insights from the randomized aldactone evaluation study (RALES). Circulation. 2000;102:2700–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, 176 74, Athens, Greece

    Chatzikyriakou Sofia, Panagiota Georgiadou, Eftihia Sbarouni & Vassilis Voudris

Authors
  1. Chatzikyriakou Sofia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Panagiota Georgiadou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eftihia Sbarouni
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vassilis Voudris
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Panagiota Georgiadou .

Editor information

Editors and Affiliations

  1. Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom

    Victor R. Preedy

  2. Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht

About this entry

Cite this entry

Sofia, C., Georgiadou, P., Sbarouni, E., Voudris, V. (2015). Chronic Heart Failure and Serum Collagen. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7696-8_14

Download citation

Publish with us

Policies and ethics

Search

Navigation