Adiponectin as Biomarker of Osteoporosis

  • Anna LubkowskaEmail author
  • Aleksandra Radecka
  • Jan Mieszkowski
Reference work entry
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series (BDMDA)


Adiponectin is one of the adipose tissue hormones synthesized and released mainly by mature adipocytes of visceral white adipose tissue. So far, scientific studies have been focused on the effect of adiponectin on regulation of glucose and fatty acid metabolism and its connection to cardiovascular system diseases and diabetes mellitus as well as the occurrence of metabolic syndrome. The latest reports indicate that this hormone is expressed not only on hepatocytes, endothelial cells, skeletal muscles, and central nervous system but also on osteoblasts, as shown by the presence of its specific membrane receptors (AdipoR1 and AdipoR2). Based on many reference data, it seems that adiponectin may be a link connecting the metabolism of adipose tissue and bone tissue. Due to its connection to bone turnover markers, it is a potential marker of osteoporosis.


Adiponectin AdipoR1 Adipo R2 Osteogenesis Osteoporosis 

List of Abbreviations


Activated protein kinase 5′


Acetyl-CoA carboxylase


Adipocyte complement related protein of 30 kDa


Adiponectin, C1Q and collagen domain containing


AMP-activated(-related) protein kinase


Anorexia nervosa


Adipocyte most abundant gene transcript 1


Bone mineral density


Body mass index


Bulimia nervosa


Dehydroepiandrosterone sulfate


Early rheumatoid arthritis


Fat mass


Gastric bypass surgery


Gelatin-binding protein of 28 kDa


Gestational diabetes mellitus


Gestational impaired glucose tolerance


Glucocorticoid receptor


High molecular weight complex


Insulin-like growth factor 1


Insulin-like growth factor 2


Interleukin 6


Laparoscopic adjustable gastric band


Low molecular weight trimer-dimer


Mitogen-activated protein kinase


Monocyte chemotactic protein

MMP-3, MMP-9

Matrix metalloproteinase 3 and 9


Middle molecular weight


Metabolic phenotype


Nitric oxide synthase 2


Normal glucose tolerance




Oral glucose load




Polycystic ovary syndrome


Peroxisome proliferator-activated receptor


Peroxisome proliferator-activated receptor alpha


Rheumatoid arthritis


Receptor activator of nuclear factor kappa-B


Receptor activator of nuclear factor kappa-B ligand


Roux-en-Y gastric bypass


Sex hormone binding globulin


Sterol regulatory element-binding protein


Diabetes mellitus type 1


Diabetes mellitus type 2


Total adiponectin level


Tumor necrosis factor alpha


Undifferentiated arthritis


Vertical banded gastroplasty


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Anna Lubkowska
    • 1
    Email author
  • Aleksandra Radecka
    • 1
  • Jan Mieszkowski
    • 2
  1. 1.Department of Functional Diagnostics and Physical Medicine, Faculty of Health SciencesPomeranian Medical University in SzczecinSzczecinPoland
  2. 2.Institute of Physical Culture, Faculty of Physical Education, Health and TourismKazimierz Wielki University in BydgoszczBydgoszczPoland

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