Skip to main content
SpringerLink
Log in
Book cover

Biomarkers in Bone Disease pp 1155–1168Cite as

Quality of Life as a Biomarker in Hip Fractures

  • Reference work entry
  • First Online:

  • 1197 Accesses

Abstract

Fractures of the hip (proximal femur) are especially common in the elderly. In this age group, they represent the leading cause of injury-related mortality and pose a great economic burden on the healthcare systems.

About all of the fractures of the proximal femur require surgery. Up to this time, there is no agreement on which type of surgery should be preferred and which implants should be used. In order to develop the best treatment plan for an individual patient, treatment results have to be assessed in a comparable way. Therefore, valid and reliable biomarkers as outcome measures are needed.

Given the high mortality after a fracture around the hip in the elderly, most commonly the mortality rates after the injury are reported. However, patients who survived the fracture commonly have significant reductions in the health-related quality of life (HRQoL). Therefore, assessing the success of the treatment solely by the survival of patients could be misleading. For this reason, it appears advantageous to report both the mortality and, if the patient has survived, the HRQoL.

In this chapter, several biomarkers as outcome measures after hip fracture are listed. In addition, efforts by several research groups are described in order to standardize the use of biomarkers after hip fractures.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   379.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

ADL:

Activities of daily living

CEA:

Cost-effective analyses

EQ-5D:

EuroQol 5 dimensions

HRQoL:

Health-related quality of life

PROM:

Patient-reported outcome measure

QALY:

Quality-adjusted life year

SF-12:

Short form 12

SF-36:

Short form 36

References

  • Adams AL, Shi J, Takayanagi M, Dell RM, Funahashi TT, Jacobsen SJ. Ten-year hip fracture incidence rate trends in a large California population, 1997–2006. Osteoporos Int. 2013;24(1):373–6.

    Article  CAS  PubMed  Google Scholar 

  • Brazier J, Roberts J, Tsuchiya A, Busschbach J. A comparison of the EQ-5D and SF-6D across seven patient groups. Health Econ. 2004;13(9):873–84.

    Article  PubMed  Google Scholar 

  • Capozzi JD, Rhodes R. Examining the ethical implications of an orthopaedic joint registry. J Bone Joint Surg Am. 2010;92(5):1330–3.

    Article  PubMed  Google Scholar 

  • Coast J, Flynn TN, Natarajan L, Sproston K, Lewis J, Louviere JJ, et al. Valuing the ICECAP capability index for older people. Soc Sci Med. 2008;67(5):874–82.

    Article  PubMed  Google Scholar 

  • de Abreu EL, de Oliveira MH. Evaluation of the quality of life of patients undergoing hemiarthroplasty of the hip. Rev Bras Ortop. 2015;50(5):530–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Desteli EE, Imren Y, Erdogan M, Aydagun O. Quality of life following treatment of trochanteric fractures with proximal femoral nail versus cementless bipolar hemiarthroplasty in elderly. Clin Invest Med. 2015;38(2):E63–72.

    Article  PubMed  Google Scholar 

  • Fleig L, McAllister MM, Brasher P, Cook WL, Guy P, Puyat JH, et al. Sedentary behavior and physical activity patterns in older adults after hip fracture: a call to action. J Aging Phys Act. 2016;24(1):79–84.

    Article  PubMed  Google Scholar 

  • Flodin L, Cederholm T, Saaf M, Samnegard E, Ekstrom W, Al Ani AN, et al. Effects of protein-rich nutritional supplementation and bisphosphonates on body composition, handgrip strength and health-related quality of life after hip fracture: a 12-month randomized controlled study. BMC Geriatr. 2015;15:149.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gerritsen DL, Steverink N, Ooms ME, de Vet HC, Ribbe MW. Measurement of overall quality of life in nursing homes through self-report: the role of cognitive impairment. Qual Life Res. 2007;16(6):1029–37.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gjertsen JE, Engesaeter LB, Furnes O, Havelin LI, Steindal K, Vinje T, et al. The Norwegian Hip Fracture Register: experiences after the first 2 years and 15,576 reported operations. Acta Orthop. 2008;79(5):583–93.

    Article  PubMed  Google Scholar 

  • Gregersen M. Postoperative red blood cell transfusion strategy in frail anemic elderly with hip fracture. A randomized controlled trial. Dan Med J. 2016;63(4).

    Google Scholar 

  • Greiner W, Weijnen T, Nieuwenhuizen M, Oppe S, Badia X, Busschbach J, et al. A single European currency for EQ-5D health states. Results from a six-country study. Eur J Health Econ. 2003;4(3):222–31.

    Article  PubMed  Google Scholar 

  • Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM. Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2005;6(2):124–130.

    Google Scholar 

  • Griffin XL, Parsons N, Achten J, Fernandez M, Costa ML. Recovery of health-related quality of life in a United Kingdom hip fracture population. The Warwick hip trauma evaluation – a prospective cohort study. Bone Joint J. 2015;97-B(3):372–82.

    Article  CAS  PubMed  Google Scholar 

  • Handoll HH, Parker MJ. Conservative versus operative treatment for hip fractures in adults. Cochrane Database Syst Rev. 2008;3:CD000337.

    Google Scholar 

  • Harris WH. Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. J Bone Joint Surg Am. 1969;51:737–55.

    Article  CAS  PubMed  Google Scholar 

  • Haywood KL, Griffin XL, Achten J, Costa ML. Developing a core outcome set for hip fracture trials. Bone Joint J. 2014;96-B(8):1016–23.

    Article  CAS  PubMed  Google Scholar 

  • Herberts P, Malchau H. How outcome studies have changed total hip arthroplasty practices in Sweden. Clin Orthop Relat Res. 1997;344:44–60.

    Article  Google Scholar 

  • Herberts P, Malchau H. Long-term registration has improved the quality of hip replacement: a review of the Swedish THR Register comparing 160,000 cases. Acta Orthop Scand. 2000;71(2):111–21.

    Article  CAS  PubMed  Google Scholar 

  • Hommel A, Baath C. A national quality registers as a tool to audit items of the fundamentals of care to older patients with hip fractures. Int J Older People Nurs. 2016;11(2):85–93. doi:10.1111/opn.12101.

    Google Scholar 

  • Hutchings L, Fox R, Chesser T. Proximal femoral fractures in the elderly: how are we measuring outcome? Injury. 2011;42(11):1205–13.

    Article  PubMed  Google Scholar 

  • Jurisson M, Pisarev H, Kanis J, Borgstrom F, Svedbom A, Kallikorm R, et al. Quality of life, resource use, and costs related to hip fracture in Estonia. Osteoporos Int. 2016;27:2555.

    Article  CAS  PubMed  Google Scholar 

  • Kempen GI, Yardley L, van Haastregt JC, Zijlstra GA, Beyer N, Hauer K, et al. The Short FES-I: a shortened version of the falls efficacy scale-international to assess fear of falling. Age Ageing. 2008;37(1):45–50.

    Article  PubMed  Google Scholar 

  • Langford DP, Fleig L, Brown KC, Cho NJ, Frost M, Ledoyen M, et al. Back to the future – feasibility of recruitment and retention to patient education and telephone follow-up after hip fracture: a pilot randomized controlled trial. Patient Prefer Adherence. 2015;9:1343–51.

    Article  PubMed  PubMed Central  Google Scholar 

  • Leonardsson O, Rolfson O, Rogmark C. The surgical approach for hemiarthroplasty does not influence patient-reported outcome: a national survey of 2118 patients with one-year follow-up. Bone Joint J. 2016;98-B(4):542–7.

    Article  CAS  PubMed  Google Scholar 

  • Liebs TR, Herzberg W, Gluth J, Ruther W, Haasters J, Russlies M, et al. Using the patient’s perspective to develop function short forms specific to total hip and knee replacement based on WOMAC function items. Bone Joint J. 2013;95-B(2):239–43.

    Article  CAS  PubMed  Google Scholar 

  • Michael D, Yaniv W, Tal FR, Kessler EG, Eyal A, Nimrod S, et al. Expandable proximal femoral nail versus gamma proximal femoral nail for the treatment of AO/OTA 31A1-3 fractures. Injury. 2016;47(2):419–23.

    Article  PubMed  Google Scholar 

  • Milte R, Miller MD, Crotty M, Mackintosh S, Thomas S, Cameron ID, et al. Cost-effectiveness of individualized nutrition and exercise therapy for rehabilitation following hip fracture. J Rehabil Med. 2016;48(4):378–85.

    Article  PubMed  Google Scholar 

  • O’Halloran PD, Sheilds N, Blackstock F, Wintle E, Taylor NF. Motivational interviewing increases physical activity and self-efficacy in people living in the community after hip fracture: a randomized controlled trial. Clin Rehabil. 2015. pii:0269215515617814. [Epub ahead of print].

    Google Scholar 

  • Panula J, Pihlajamaki H, Mattila VM, Jaatinen P, Vahlberg T, Aarnio P, et al. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011;12:105.

    Article  PubMed  PubMed Central  Google Scholar 

  • Parsons N, Griffin XL, Achten J, Costa ML. Outcome assessment after hip fracture: is EQ-5D the answer? Bone Joint Res. 2014;3(3):69–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Qualitätsreport 2013. Göttingen, AQUA – Institut für angewandte Qualitätsförderung und Forschung im Gesundheitswesen GmbH. 2014.

    Google Scholar 

  • Roberts SE, Goldacre MJ. Time trends and demography of mortality after fractured neck of femur in an English population, 1968–98: database study. BMJ. 2003;327(7418):771–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rolfson O, Karrholm J, Dahlberg LE, Garellick G. Patient-reported outcomes in the Swedish Hip Arthroplasty Register: results of a nationwide prospective observational study. J Bone Joint Surg (Br). 2011;93(7):867–75.

    Article  CAS  Google Scholar 

  • Svedbom A, Hernlund E, Ivergard M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos. 2013;8:137.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • The Whoqol Group. The World Health Organization Quality of Life Assessment (WHOQOL): development and general psychometric properties. Soc Sci Med. 1998;46(12):1569–85.

    Google Scholar 

  • Tseng MY, Liang J, Shyu YI, Wu CC, Cheng HS, Chen CY, et al. Effects of interventions on trajectories of health-related quality of life among older patients with hip fracture: a prospective randomized controlled trial. BMC Musculoskelet Disord. 2016;17(1):114.

    Article  PubMed  PubMed Central  Google Scholar 

  • Uzoigwe CE, Burnand HG, Cheesman CL, Aghedo DO, Faizi M, Middleton RG. Early and ultra-early surgery in hip fracture patients improves survival. Injury. 2013;44(6):726–9.

    Article  PubMed  Google Scholar 

  • Wajanavisit W, Woratanarat P, Sawatriawkul S, Lertbusayanukul C, Ongphiphadhanakul B. Cost-utility analysis of osteoporotic hip fractures in thais. J Med Assoc Thai. 2015;98 Suppl 8:S65–9.

    PubMed  Google Scholar 

  • Ware Jr JE, Kosinski M, Bayliss MS, McHorney CA, Rogers WH, Raczek A. Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study. Med Care. 1995;33(4 Suppl):AS264–79.

    PubMed  Google Scholar 

  • Warschawski Y, Sharfman ZT, Berger O, Steinberg EL, Amar E, Snir N. Dynamic locking plate vs. simple cannulated screws for nondisplaced intracapsular hip fracture: a comparative study. Injury. 2016;47(2):424–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatric Orthopaedics and Paediatric Traumatology, Inselspital, University of Bern, University Clinic for Paediatric Surgery, Freiburgstrasse 4, 3010, Bern, Switzerland

    Thoralf Randolph Liebs

Authors
  1. Thoralf Randolph Liebs
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thoralf Randolph Liebs .

Editor information

Editors and Affiliations

  1. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media Dordrecht

About this entry

Cite this entry

Liebs, T.R. (2017). Quality of Life as a Biomarker in Hip Fractures. In: Patel, V., Preedy, V. (eds) Biomarkers in Bone Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7693-7_48

Download citation

Publish with us

Policies and ethics

Search

Navigation