Biomarkers in Osteoarthritis: Value of Proteomics

  • Cristina Ruiz-RomeroEmail author
  • Patricia Fernández-PuenteEmail author
  • Francisco J. BlancoEmail author
Reference work entry
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series (BDMDA)


Osteoarthritis (OA) is the most common rheumatic pathology accounting for much of worldwide disability. OA is related to aging and may affect the structure of any joint tissue. The early stage accurate diagnosis of OA and the ability to monitor the efficacy of putative disease-modifying drugs remain among the essential unmet medical needs for this disease. Despite the prevalence of OA, the diagnostic methods currently available are limited and lack sensitivity. Furthermore, there is currently no effective therapy capable of slowing or reversing the pathological changes that occur in the joint during the disease process. Therefore, the discovery and application of novel, noninvasive, specific biochemical markers remain a priority. This chapter will focus on the current OA protein markers and the value of proteomics for the discovery and validation of useful candidates for early diagnosis and drug discovery.


Biomarkers Osteoarthritis Proteomics Cartilage Synovium Synovial fluid Mass spectrometry 

List of Abbreviations


Two-dimensional gel electrophoresis


Type II collagen


Cartilage oligomeric matrix protein


Chondroitin sulfate


C-telopeptide region of COL2


Differential in-gel electrophoresis


Hyaluronic acid


Healthy controls


Isobaric tag for relative quantitation


Kellgren and Lawrence scale


Keratan sulfate


Liquid chromatography


Matrix-assisted laser desorption/ionization-time of flight


Magnetic beads


Matrix metalloproteinases


Mass spectrometry


Nucleic acid programmable protein array




Osteoarthritis Research Society International


Polyacrylamide gel electrophoresis


Psoriatic arthritis


Rheumatoid arthritis


Surface-enhanced laser desorption/ionization


Synovial fluid


Selected reaction monitoring


Tissue inhibitor of matrix metalloproteinase




Cartilage glycoprotein 39


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Grupo de Proteómica, ProteoRed-PRB2/ISCIIIServicio de Reumatología. Instituto de Investigación Biomédica (INIBIC). Complexo Hospitalario Universitario A Coruña (CHUAC). Sergas. Universidad de A Coruña (UDC)A CoruñaSpain
  2. 2.Rheumatology DivisonINIBIC-Hospital Universitario A CoruñaA CoruñaSpain
  3. 3.Proteomics UnitINIBIC-Hospital Universitario A CoruñaA CoruñaSpain

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