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Tartrate-Resistant Acid Phosphatase as a Biomarker of Bone Remodeling

  • Divya VohoraEmail author
  • Bushra Parveen
Reference work entry
  • 842 Downloads
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series (BDMDA)

Abstract

Tartrate-resistant acid phosphatase (TRACP) is an enzyme abundantly expressed in tissues such as the bone, spleen, liver, lungs, and skin. It has two isoforms, namely, TRACP 5a and TRACP 5b. TRACP 5a is specific for the placenta and lungs, whereas TRACP 5b is exclusive to the bone, spleen, thymus, kidney, colon, and brain. This chapter discusses the physiological functions as well as the pathological conditions associated with TRACP. While TRACP 5a is a prognostic marker for chronic inflammation, TRCAP 5b is a marker of osteoclast number. Plethora of studies revealed its importance in treatment monitoring, owing to absence of diurnal fluctuations, food effect, and accumulation in renal and liver impairment. Through this work, an effort has been made to collate the scientific information on the role and mechanism of TRACP in bone resorption and its advantages over other bone markers.

Keywords

Tartrate-resistant acid phosphatase TRACP 5a TRACP 5b Bone resorption Osteoclast number 

List of Abbreviations

AOD2

Type II autosomal dominant osteopetrosis

AP

Acid phosphatase

BMPs

Bone morphogenetic protein

Cbfa1

Core-binding factor alpha 1

CRP

C-reactive protein

CTX

Collagen-type 1 cross-linked C-telopeptide

FSD

Functional secretory domain

FSD

Functional secretory domain

GLP-2

Glucagon-like peptide 2

HRT

Hormone replacement therapy

IGF-1

Insulin-like growth factor 1

IgM

Immunoglobulin M

IL-6

Interleukin 6

kD

Kilo Dalton

NF-kB

Nuclear factor kappa B

NTX

Amino-terminal collagen cross-link

OA

Osteoarthritis

ODF

Osteoclast differentiation factor

OPGL

Osteoprotegerin ligand

PAP

Plant acid phosphatase

PCR

Polymerase chain reaction

RA

Rheumatoid arthritis

RANKL

Receptor-activated nuclear factor kappa ligand

ROS

Reactive oxygen species

TGF-β

Tumor growth factor β

TRACP

Tartrate-resistant acid phosphatase

TRANCE

Tumor necrosis factor-related activation-induced cytokine

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© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Faculty of PharmacyJamia HamdardNew DelhiIndia

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