Bone-Specific Alkaline Phosphatase and Exercise

  • Alev AlpEmail author
Reference work entry
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series (BDMDA)


It is a matter of discussion how physical exercise affects bone remodeling process and markers such as bone-specific alkaline phosphatase (BAP) which is the only marker that is not influenced by diurnal variation of bone remodeling. Dietary calcium intake and parathormone levels are strongly associated with the remodeling status during or after the physical training, and increase of BAP levels may not be always the indicator of bone formation process. Moreover, behavior of BAP may be different in physically active or sedentary people at different ages and sexes. Because skeletal muscle has the ability to adapt to a variety of changes in physical status, physical exercise has the ability to change turnover status in favor of formation by increasing BAP/pyridinoline ratio.


Biomarker Bone formation Bone-specific alkaline phosphatase Bone remodeling Bone turnover Exercise 

List of Abbreviations


Bone-specific alkaline phosphatase


Bone mineral density


Basic multicellular unit


C-terminal telopeptide


Dual-energy X-ray absorptiometry


Free deoxypyridinoline




Low-density lipoprotein receptor-related protein 5


N-terminal telopeptide




C-terminal propeptide of type 1 collagen


N-terminal propeptide of type 1 procollagen


Free pyridinoline


Receptor activator of nuclear factor kappa-B ligand


Tartrate-resistant acid phosphatase


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Department of Physical Therapy and Rehabilitation (Atatürk Balneotherapy and Rehabilitation Center), Faculty of MedicineUludag UniversityOsmangaziTurkey

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