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Bone-Specific Alkaline Phosphatase and Exercise

  • Alev AlpEmail author
Reference work entry
  • 846 Downloads
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series (BDMDA)

Abstract

It is a matter of discussion how physical exercise affects bone remodeling process and markers such as bone-specific alkaline phosphatase (BAP) which is the only marker that is not influenced by diurnal variation of bone remodeling. Dietary calcium intake and parathormone levels are strongly associated with the remodeling status during or after the physical training, and increase of BAP levels may not be always the indicator of bone formation process. Moreover, behavior of BAP may be different in physically active or sedentary people at different ages and sexes. Because skeletal muscle has the ability to adapt to a variety of changes in physical status, physical exercise has the ability to change turnover status in favor of formation by increasing BAP/pyridinoline ratio.

Keywords

Biomarker Bone formation Bone-specific alkaline phosphatase Bone remodeling Bone turnover Exercise 

List of Abbreviations

BAP

Bone-specific alkaline phosphatase

BMD

Bone mineral density

BMU

Basic multicellular unit

CTX

C-terminal telopeptide

DEXA

Dual-energy X-ray absorptiometry

D-PYR

Free deoxypyridinoline

HYP

Hydroxyproline

LRP5

Low-density lipoprotein receptor-related protein 5

NTX

N-terminal telopeptide

OC

Osteocalcin

PICP

C-terminal propeptide of type 1 collagen

PINP

N-terminal propeptide of type 1 procollagen

PYD

Free pyridinoline

RANKL

Receptor activator of nuclear factor kappa-B ligand

TRAP

Tartrate-resistant acid phosphatase

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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Department of Physical Therapy and Rehabilitation (Atatürk Balneotherapy and Rehabilitation Center), Faculty of MedicineUludag UniversityOsmangaziTurkey

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