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Use of Alkaline Phosphatase (ALP) Activity and Disease Severity to Determine Secular Changes in Bone Disease as Applied to Paget’s Disease of the Bone

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Biomarkers in Bone Disease

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Abstract

A decrease in the prevalence of Paget’s disease of the bone during recent decades has been reported for different research groups. In addition to this change in prevalence, some authors have suggested a reduction in the severity of the disease. This secular change has been documented by a reduction in the extension of skeletal involvement and the finding of lower levels of ALP at diagnosis. The reasons for the change in prevalence and severity are poorly understood. Genetic factors which confer susceptibility for Paget’s disease, as SQSTM1 gene mutations, and their role on the severity of the disease have been suggested as possible explanation. Other factors, as the demographical or sociological changes in the susceptible populations, have been postulated as alternative hypothesis.

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Abbreviations

ALP:

Alkaline phosphatase

CSF1:

Colony stimulating factor 1

NUP205:

Nucleoporin 205-KD

OPTN:

Optineurin

PINP:

Procollagen type I N-terminal propeptide

PML:

Promyelocytic leukemia

RIN3:

Ras and Rab interactor 3

SQSTM1:

Sequestosome 1 human protein

TM7SF4:

Transmembrane 7 superfamily, member 4

TNFRS:

Tumor necrosis factor receptor superfamily

UK:

United Kingdom

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Authors and Affiliations

  1. Internal Medicine Department, Hospital el Bierzo, Médicos sin Fronteras n°7, Fuentesnuevas, CP: 24411, Ponferrada, León, Spain

    Luis Corral-Gudino

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  1. Luis Corral-Gudino
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Correspondence to Luis Corral-Gudino .

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  1. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

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Corral-Gudino, L. (2017). Use of Alkaline Phosphatase (ALP) Activity and Disease Severity to Determine Secular Changes in Bone Disease as Applied to Paget’s Disease of the Bone. In: Patel, V., Preedy, V. (eds) Biomarkers in Bone Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7693-7_2

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