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Whole Blood Transcriptome and Other Biomarkers in Nasopharyngeal Cancer

  • Reference work entry
Biomarkers in Cancer

  • 1935 Accesses

Abstract

Nasopharyngeal carcinoma is often diagnosed only after the disease has reached late stages and the prognosis is poor. However, when detected early, the disease is highly survivable. This review surveys molecular biomarker studies that aim to identify early, presymptomatic disease, to predict response to treatment, to indicate prognosis, to identify tumor stage, and to monitor disease progression. Blood transcriptomic studies represent a new frontier in the molecular diagnostics of nasopharyngeal carcinoma.

Chun Ren Lim and Michelle Lee contributed equally to this manuscript

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Abbreviations

AUC:

Area Under the Curve

BCR:

B-cell Receptor

CR:

Complete Response to Treatment

CT:

Computed Tomography

DNA:

Deoxyribonucleic Acid

EBV:

Epstein-Barr Virus

EGFR1:

Epidermal Growth Factor Receptor 1

ELISA:

Enzyme-Linked Immunosorbent Assay

GWAS:

Genome-Wide Association Study

HLA:

Human Leukocyte Antigen

IgA:

Immunoglobulin A

IgG:

Immunoglobulin G

MHC:

Major Histocompatibility Complex

miRNA:

MicroRNA

MRI:

Magnetic Resonance Imaging

mRNA:

Messenger RNA

NPC:

Nasopharyngeal Carcinoma

PCR:

Polymerase Chain Reaction

PR:

Partial Response to Treatment

RNA:

Ribonucleic Acid

ROC:

Receiver Operating Characteristic Curve

SELDI-TOF-MS:

Surface-Enhanced Laser Desorption and Ionization-Time-of-Flight Mass Spectrometry

SNP:

Single Nucleotide Polymorphism

TNF:

Tumor Necrosis Factor

TNFR:

Tumor Necrosis Factor Receptor

TSG:

Tumor Suppressor Gene

VCA:

Viral Capsid Antigen

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    Authors and Affiliations

    1. GeneNews (Malaysia) Limited, Georgetown, Penang, Malaysia

      Chun Ren Lim & Michelle Mei Lin Lee

    2. GeneNews Limited, Markham, ON, Canada

      Samuel Chao

    3. Gleneagles Medical Centre, Penang, Malaysia

      Adel Zaatar

    4. GeneNews Diagnostics, Kuala Lumpur, Malaysia

      Choong Chin Liew

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    1. Faculty of Life Sciences & Medicine King’s College London, Department of Nutrition and Dietetics Division of Diabetes & Nutritional Scien, London, United Kingdom

      Victor R. Preedy

    2. Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

      Vinood B. Patel

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    Lim, C.R., Lee, M.M.L., Chao, S., Zaatar, A., Liew, C.C. (2015). Whole Blood Transcriptome and Other Biomarkers in Nasopharyngeal Cancer. In: Preedy, V., Patel, V. (eds) Biomarkers in Cancer. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7681-4_3

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