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Biomarkers in Cardiovascular Disease pp 955–984Cite as

Markers of Cardiac Resynchronization Therapy

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Abstract

Despite the well-recognized benefits of CRT, an unsolved problem is the fact that based on the current selection criteria up to 30 % of patients do not respond to this therapy. Therefore, it is of paramount importance to try to identify more precisely patients who will derive the best benefit of this invasive therapy. Patient selection for CRT should involve a multimodal approach, and new promising tools may help in this difficult process. In this chapter, we will briefly discuss the impact of CRT in the expression of several biomarkers and also their role as predictors of CRT response, namely endothelial progenitor cells, brain natriuretic peptide, inflammatory mediators, biological markers, and renal function.

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Abbreviations

BNP:

Brain natriuretic peptide

CKD:

Chronic kidney disease

CRT:

Cardiac resynchronization therapy

EPCs:

Endothelial Progenitor Cells

GFR:

glomerular Filtration Rate

HF:

Heart Failure

hs-CRP:

high sensitivity C Reactive Protein

ICTP:

carboxyterminal telopeptide of type I collagen

LV:

Left Ventricular

LVESV:

left ventricular end-systolic volume

MDRD:

Modification of Diet in Renal Disease

NYHA:

New York Heart Association

NT- proBNP:

terminal fragment pro-brain natriuretic peptide

NP:

Natriuretic peptides

HF:

Heart Failure

TNFα:

Tumor Necrosis Factor α

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Authors and Affiliations

  1. Cardiology Department, Coimbra University Hospital and Medical School, Serviço de Cardiologia, Hospitais da Universidade de Coimbra, Avenida Bissaya Barreto, 3000-076, Coimbra, Portugal

    Joana Moura Ferreira, Ana Rita Ferreira, Luís Leite, Manuel Oliveira Santos, Luís Elvas & Natália António

  2. Institute of Pharmacology and Experimental Therapeutics – Biomedical Institute for Research in Light and Image (IBILI), Faculty of Medicine, Coimbra University, Coimbra, Portugal

    Natália António

Authors
  1. Joana Moura Ferreira
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  2. Ana Rita Ferreira
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  3. Luís Leite
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  4. Manuel Oliveira Santos
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  5. Luís Elvas
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  6. Natália António
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Corresponding author

Correspondence to Natália António .

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Editors and Affiliations

  1. Department of Biomedical Science, Faculty of Science & Technology , University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

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Ferreira, J.M., Ferreira, A.R., Leite, L., Santos, M.O., Elvas, L., António, N. (2016). Markers of Cardiac Resynchronization Therapy. In: Patel, V., Preedy, V. (eds) Biomarkers in Cardiovascular Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7678-4_51

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