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Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Liver Disease

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Biomarkers in Liver Disease

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Abstract

Cell adhesion molecules belong to a family called glycoproteins. They are involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In particular, vascular cell adhesion molecule-1 (VCAM-1) can bind to leucocyte integrin very late antigen-4 (VLA-4) to recruit leucocytes to sites of inflammation. Thus, VCAM-1 stimulates adhesion of lymphocyte and monocytes to the surface of the vascular endothelium.

There is evidence that soluble VCAM-1 concentration is increased in patients with liver disease, in comparison to control subjects, and, for this reason, it could be used as a biomarker to early identify liver disease. At this regard, the aim of this chapter will be to examine the role of VCAM-1 expression in liver disease.

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Abbreviations

ICAMs:

Intercellular adhesion molecules

IL-1β:

Interleukin-1β

IL-4:

Interleukin-4

IL-6:

Interleukin-6

NAFLD:

Nonalcoholic fatty liver disease

TNF-α:

Tumor necrosis factor-α

VCAM-1:

Vascular cell adhesion molecule-1

VLA-4:

Very late antigen-4

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Authors and Affiliations

  1. Department of Internal Medicine and Therapeutics, University of Pavia, P.le C. Golgi, 2, 27100, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  2. Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  3. Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  4. Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  5. PhD School in Experimental Medicine, University of Pavia, Pavia, Italy

    Pamela Maffioli

Authors
  1. Giuseppe Derosa
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  2. Pamela Maffioli
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Corresponding authors

Correspondence to Giuseppe Derosa or Pamela Maffioli .

Editor information

Editors and Affiliations

  1. Department of Biomedical Science, Faculty of Science and Technology, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Diabetes and Nutritional Sciences Research Division, Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

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Derosa, G., Maffioli, P. (2017). Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Liver Disease. In: Patel, V., Preedy, V. (eds) Biomarkers in Liver Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7675-3_24

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