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Burkholderia pseudomallei Toxins and Clinical Implications

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Microbial Toxins

Part of the book series: Toxinology ((TOXI))

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Abstract

Burkholderia pseudomallei is the causal agent of melioidosis. In spite of ongoing studies, the molecular mechanisms underlying toxin-induced pathogenesis of this bacterium are not clearly elucidated for this potential biological warfare pathogen. In this review, we highlight current information of B. pseudomallei toxins and their roles in pathophysiological effects in various experimental models. Several secretary proteins/lethal factors show lethal toxicity to cells in culture via filtrates of B. pseudomallei culture. These toxins are released in culture from strains isolated from soil, animals and humans. Toxins are also found in infected patients, which strongly correlate with severity of melioidosis. Melioidosis progression begins with an environmental reservoir and bacterial attachment in the host, invasion of epithelial/macrophage cells and subsequent intercellular spread. The molecular and cellular basis of pathogenesis in melioidosis will provide a better, rational understanding toward design and development of new drugs with novel mechanisms of action.

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Authors and Affiliations

  1. Venom and Toxin Research Programme, Department of Anatomy, National University of Singapore, Singapore, Singapore

    Ramar Perumal Samy & P. Gopalakrishnakone

  2. Department of Physiology, NUS Immunology Programme, Centre for Life Sciences, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, 117456, Singapore, Singapore

    Ramar Perumal Samy, Sok Lin Foo & Lina H. K. Lim

  3. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Gautam Sethi

  4. Integrated Toxicology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MA, USA

    Bradley G. Stiles

  5. Centro de Análises Proteômicas e Bioquímicas/Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, UCB, 10S-inova, Brasília, DF, Brazil

    Octavio Luiz Franco

  6. S. Inova Biotech Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil

    Octavio Luiz Franco

  7. School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, 6009, Perth, WA, Australia

    Frank Arfuso

  8. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore

    Sok Lin Foo & Lina H. K. Lim

  9. Department of Biology, Wilson College, Chambersburg, PA, USA

    Bradley G. Stiles

Authors
  1. Ramar Perumal Samy
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  2. Gautam Sethi
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  3. Bradley G. Stiles
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  4. Sok Lin Foo
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  5. Octavio Luiz Franco
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  6. Frank Arfuso
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  7. Lina H. K. Lim
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  8. P. Gopalakrishnakone
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Corresponding author

Correspondence to Ramar Perumal Samy .

Editor information

Editors and Affiliations

  1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    P. Gopalakrishnakone

  2. Biology Department, Wilson College , Chambersburg, Pennsylvania, USA

    Brad Stiles

  3. Department of Biochemistry, School of Medicine and Instituto Clodomiro Picado, Faculty of Microbiology, University of Costa Rica , San Pedro de Montes de Oca, Costa Rica

    Alberto Alape-Girón

  4. Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal , Saint-Hyacinthe, Canada

    J. Daniel Dubreuil

  5. College of Pharmacy, Roseman University of Health Sciences, Henderson, Nevada, USA

    Manas Mandal

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Samy, R.P. et al. (2017). Burkholderia pseudomallei Toxins and Clinical Implications. In: Gopalakrishnakone, P., Stiles, B., Alape-Girón, A., Dubreuil, J., Mandal, M. (eds) Microbial Toxins. Toxinology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6725-6_12-2

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  • DOI: https://doi.org/10.1007/978-94-007-6725-6_12-2

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-6725-6

  • Online ISBN: 978-94-007-6725-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Chapter history

  1. Latest

    Toxins and Clinical Implications
    Published:
    28 June 2017

    DOI: https://doi.org/10.1007/978-94-007-6725-6_12-2

  2. Original

    Toxins and Clinical Implications
    Published:
    04 November 2016

    DOI: https://doi.org/10.1007/978-94-007-6725-6_12-1

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