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Physiology and Pathology of the Anomeric Specificity for the Glucose-Induced Secretory Response of Insulin-, Glucagon-, and Somatostatin-Producing Pancreatic Islet Cells

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Islets of Langerhans

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Abstract

This review deals with the anomeric specificity of the secretory response of insulin-, glucagon-, and somatostatin-producing cells to d-glucose and d-mannose. In a physiological perspective, emphasis is placed on the experimental findings documenting such an anomeric specificity and its possible determinants, including consideration on the essential role of the anomeric specificity of phosphoglucoisomerase, phosphomannoisomerase, and phosphoglucomutase. The possible role of mutarotase, glucokinase, and a sweet taste receptor is also discussed. The anomeric specificity of the metabolic and functional response to d-glucose in tumoral islet cells is briefly considered. In a pathological perspective, perturbations of such an anomeric specificity in both diabetic subjects and a number of animal models with altered pancreatic islet status are presented. This review thus represents an updated contribution on the anomeric specificity of the metabolic and functional responses of the three major types of islet endocrine cells to selected hexoses.

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References

  • Barreto M, Valverde I, Malaisse WJ (1987) Anomeric specificity of glucose-stimulated protein biosynthesis in tumoral pancreatic islet cells. Med Sci Res 15:1103–1104

    CAS  Google Scholar 

  • Catala J, Bonnafous R, Hollande E (1986) Disturbances in the regulation of glycaemia in rabbits following pancreatic duct-ligation. Biochemical and immunocytochemical studies. Diabet Metab 12:203–211

    CAS  Google Scholar 

  • Courtois P, Bource F, Sener A, Malaisse WJ (2000) Anomeric specificity of human liver and β-cell glucokinase: modulation by the glucokinase regulatory protein. Arch Biochem Biophys 373:126–134

    Article  PubMed  CAS  Google Scholar 

  • Fichaux F, Marchand J, Yaylali B, Leclercq-Meyer V, Catala J, Malaisse WJ (1991) Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas. Int J Pancreatol 8:151–167

    PubMed  CAS  Google Scholar 

  • Grill V, Cerasi E (1975) Glucose-induced cyclic AMP accumulation in rat islets of Langerhans: preferential effect of the α anomer. FEBS Lett 54:80–83

    Article  PubMed  CAS  Google Scholar 

  • Grodsky GM, Fanska R, West L, Manning M (1974) Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor? Science 186:536–538

    Article  PubMed  CAS  Google Scholar 

  • Grodsky GM, Fanska R, Lundquist J (1975) Interrelationships between α and β anomers of glucose affecting both insulin and glucagon secretion by the perfused rat pancreas. Endocrinology 97:573–580

    Article  PubMed  CAS  Google Scholar 

  • Leclercq-Meyer V, Woussen-Colle M-C, Lalieu C, Marchand J, Malaisse WJ (1987a) Anomeric specificity of glucose-induced somatostatin secretion. Experientia 43:1216–1218

    Article  PubMed  CAS  Google Scholar 

  • Leclercq-Meyer V, Marchand J, Malaisse WJ (1987b) Anomeric specificity of the insulin and glucagon secretory response to d-glucose in lean and obese Zucker rats. Pancreas 2:645–652

    Article  PubMed  CAS  Google Scholar 

  • Leclercq-Meyer V, Marchand J, Malaisse WJ (1987c) Alteration of the insulin secretory response to d-glucose anomers in diabetic BB rats. Med Sci Res 15:1535–1536

    CAS  Google Scholar 

  • Leclercq-Meyer V, Marchand J, Malaisse WJ (1991) Attenuated anomeric difference of glucose-induced insulin release in the perfused pancreas of diazoxide-treated rats. Horm Metab Res 23:257–261

    Article  PubMed  CAS  Google Scholar 

  • Leclercq-Meyer V, Malaisse-Lagae F, Coulic V, Akkan AG, Malaisse WJ (1992) Preservation of the anomeric specificity of glucose-induced insulin release in partially pancreatectomized rats. Diabetologia 35:505–509

    Article  PubMed  CAS  Google Scholar 

  • Leclercq-Meyer V, Marchand J, Malaisse WJ (1993) Effect of starvation upon the anomeric specificity of glucose-induced insulin release. Diabet Nutr Metab 6:129–134

    Google Scholar 

  • Levy J, Herchuelz A, Sener A, Malaisse WJ (1976) The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: a model for altered glucose recognition by the β-cell. Metabolism 25:583–591

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ (1987) Insulin release: the glucoreceptor myth. Med Sci Res 15:65–67

    CAS  Google Scholar 

  • Malaisse WJ (1990) Physiology and pathology of the pancreatic β-cell glucose-sensor device. The Morgagni prize lecture. In: Crepaldi G, Tiengo A, Enzi G (eds) Diabetes, obesity and hyperlipidemias. Elsevier Science, Amsterdam, pp 3–22

    Google Scholar 

  • Malaisse WJ (1991) The anomeric malaise: a manifestation of β-cell glucotoxicity. Horm Metab Res 23:307–311

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ (1998) The riddle of l-glucose pentaacetate insulinotropic action. Int J Mol Med 2:383–388

    PubMed  CAS  Google Scholar 

  • Malaisse WJ, Bodur H (1991) Hexose metabolism in pancreatic islets. Enzyme-to-enzyme tunnelling of hexose 6-phosphates. Int J Biochem 23:1471–1481

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ, Malaisse-Lagae F (1992) Hexose metabolism in pancreatic islets. Oxidative response to d-glucose in fed and starved rats. Acta Diabetol 29:94–98

    Article  CAS  Google Scholar 

  • Malaisse WJ, Sener A (1985) Glucokinase is not the pancreatic β-cell glucoreceptor. Diabetologia 28:520–527

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ, Sener A, Koser M, Herchuelz A (1976a) The stimulus-secretion coupling of glucose-induced insulin release. XXIV. The metabolism of α- and β-d-glucose in isolated islets. J Biol Chem 251:5936–5943

    PubMed  CAS  Google Scholar 

  • Malaisse WJ, Sener A, Koser M, Herchuelz A (1976b) Identification of the α-stereospecific glucosensor in the pancreatic β-cell. FEBS Lett 65:131–134

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ, Malaisse-Lagae F, Sener A (1983a) Anomeric specificity of hexose metabolism in pancreatic islets. Physiol Rev 63:321–327

    Google Scholar 

  • Malaisse WJ, Deleers M, Malaisse-Lagae F, Sener A (1983b) Anomeric specificity of hexose metabolism in pancreatic islets. In: Mngola EN (ed) Diabetes 1982, vol 600. Excerpta medica ICS. pp 345–351

    Google Scholar 

  • Malaisse WJ, Giroix M-H, Dufrane SP, Malaisse-Lagae F, Sener A (1985a) Anomeric specificity of glucose metabolism in a non glucokinase-containing cell. Biochem Int 10:233–240

    PubMed  CAS  Google Scholar 

  • Malaisse WJ, Giroix M-H, Dufrane SP, Malaisse-Lagae F, Sener A (1985b) Environmental modulation of the anomeric specificity of glucose metabolism in normal and tumoral cells. Biochim Biophys Acta 847:48–52

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ, Giroix M-H, Sener A (1985c) Anomeric specificity of glucose metabolism in the pentose cycle. J Biol Chem 260:14630–14632

    PubMed  CAS  Google Scholar 

  • Malaisse WJ, Malaisse-Lagae F, Leclercq-Meyer V (1988) Anomeric specificity of hexose metabolism in health and disease. Neth J Med 33:247–256

    PubMed  CAS  Google Scholar 

  • Malaisse WJ, Giroix M-H, Zähner D, Marynissen G, Sener A, Portha B (1991) Neonatal streptozotocin injection : a model of glucotoxicity? Metabolism 40:1101–1105

    Article  PubMed  CAS  Google Scholar 

  • Malaisse WJ, Maggetto C, Leclercq-Meyer V, Sener A (1993) Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats. J Clin Invest 91:432–436

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Malaisse WJ, Vanonderbergen A, Louchami K, Jijakli H, Malaisse-Lagae F (1998) Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets. Cell Signal 10:727–733

    Article  PubMed  CAS  Google Scholar 

  • Malaisse-Lagae F, Malaisse WJ (1986) Abnormal identification of the sweet taste of d-glucose anomers. Diabetologia 29:344–345 (Letter)

    Article  PubMed  CAS  Google Scholar 

  • Malaisse-Lagae F, Sener A, Malaisse WJ (1982a) Phospho-glucomutase: its role in the response of pancreatic islets to glucose epimers and anomers. Biochimie 64:1059–1063

    Article  PubMed  CAS  Google Scholar 

  • Malaisse-Lagae F, Sener A, Lebrun P, Herchuelz A, Leclercq-Meyer V, Malaisse WJ (1982b) Réponse sécrétoire, ionique et métabolique des îlots de Langerhans aux anomères du D-mannose. CR Acad Sci (Paris) 294(III):605–607

    CAS  Google Scholar 

  • Malaisse-Lagae F, Willem R, Penders M, Malaisse WJ (1992) Dual anomeric specificity of phosphomannoisomerase assessed by 2D phase sensitive 13C EXSY NMR. Mol Cell Biochem 115:137–142

    PubMed  CAS  Google Scholar 

  • Marynissen G, Leclercq-Meyer V, Sener A, Malaisse WJ (1990) Perturbation of pancreatic islet function in glucose-infused rats. Metabolism 39:87–95

    Article  PubMed  CAS  Google Scholar 

  • Matschinsky FM, Pagliara AS, Hover BA, Haymond MW, Stillings SN (1975a) Differential effects of α- and β-d-glucose on insulin and glucagon secretion from the isolated perfused rat pancreas. Diabetes 24:369–372

    Article  PubMed  CAS  Google Scholar 

  • Matschinsky FM, Ellerman J, Stillings S, Rayband F, Pace C, Zawalich W (1975b) Hexoses and insulin secretion. In: Hasseblatt A, von Bruchhausen F (eds) Insulin, part 2. Springer, Heidelberg, pp 79–114

    Google Scholar 

  • Meglasson MD, Matschinsky FM (1983) Discrimination of glucose anomers by glucokinase from liver and transplantable insulinoma. J Biol Chem 258:6705–6708

    PubMed  CAS  Google Scholar 

  • Meglasson DM, Schinco M, Matschinsky FM (1983) Mannose phosphorylation by glucokinase from liver and transplantable insulinoma. Cooperativity and discrimination of anomers. Diabetes 32:1146–1151

    Article  PubMed  CAS  Google Scholar 

  • Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami M, Nikolaev VO et al (2009) Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS ONE 4:e5106

    Article  PubMed  PubMed Central  Google Scholar 

  • Nakagawa Y, Nagasawa M, Mogami H, Lohse M, Ninomiya Y, Kojima J (2013a) Multimodal function of sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists. Endocr J 60:1191–1206

    Article  PubMed  CAS  Google Scholar 

  • Nakagawa Y, Ohtsu Y, Nagasawa M, Shibata H, Kojima I (2013b) Glucose promotes its own metabolism by acting on the cell surface glucose-sensing receptor T1R3. Endocr J. doi:10.1507

    Google Scholar 

  • Niki A, Niki H, Miwa I, Okuda J (1974) Insulin secretion by anomers of d-glucose. Science 186:150–151

    Article  PubMed  CAS  Google Scholar 

  • Niki A, Niki H, Miwa I, Lin BJ (1976) Interaction of alloxan and anomers of d-glucose on glucose-induced insulin secretion and biosynthesis in vitro. Diabetes 25:574–579

    Article  PubMed  CAS  Google Scholar 

  • Niki A, Niki H, Ozawa T (1977) Induction of insulin biosynthesis by anomers of d-glucose. FEBS Lett 80:5–8

    Article  PubMed  CAS  Google Scholar 

  • Niki A, Niki H, Miwa I (1979) Effect of anomers of D-mannose on insulin release from perfused rat pancreas. Endocrinology 105:1051–1054

    Article  PubMed  CAS  Google Scholar 

  • Niki A, Niki H, Niki I, Kunoh Y (1988) Insulin release by glucose anomers in a rat model of non-insulin-dependent diabetes. Diabetologia 31:65–67

    PubMed  CAS  Google Scholar 

  • Pierce M, Freinkel N (1975) Anomeric specificity for the rapid transient efflux of phosphate ions from pancreatic islets during secretory stimulation with glucose. Biochem Biophys Res Commun 63:870–874

    Article  PubMed  CAS  Google Scholar 

  • Rasschaert J, Zähner D, Malaisse WJ (1987) Low mutarotase activity in normal and tumoral pancreatic islet cells. Med Sci Res 15:621–622

    CAS  Google Scholar 

  • Rossini AA, Soeldner JS, Hiebert JM, Weir GC, Gleason RE (1974a) The effect of glucose anomers upon insulin and glucagon secretion. Diabeologia 10:795–799

    Article  CAS  Google Scholar 

  • Rossini AA, Berger M, Shadden J, Cahill GF Jr (1974b) β cell protection to alloxan necrosis by anomers of d-glucose. Science 183:424

    Article  PubMed  CAS  Google Scholar 

  • Rossini AA, Arcangeli MA, Cahill GF Jr (1975) Studies of alloxan toxicity on the β cell. Diabets 24:516–522

    Article  CAS  Google Scholar 

  • Rovira A, Garrotte FJ, Valverde I, Malaisse WJ (1987) Anomeric specificity of glucose-induced insulin release in normal and diabetic subjects. Diabet Res 5:119–124

    CAS  Google Scholar 

  • Sener A, Malaisse-Lagae F, Malaisse WJ (1982a) Glucose-induced accumulation of glucose-1, 6-bisphosphate in pancreatic islets: its possible role in the regulation of glycolysis. Biochem Biophys Res Commun 104:1033–1040

    Article  PubMed  CAS  Google Scholar 

  • Sener A, Malaisse-Lagae F, Lebrun P, Herchuelz A, Leclercq-Meyer V, Malaisse WJ (1982b) Anomeric specificity of d-mannose metabolism in pancreatic islets. Biochem Biophys Res Commun 108:1567–1573

    Article  PubMed  CAS  Google Scholar 

  • Sener A, Giroix M-H, Leclercq-Meyer V, Marchand J, Malaisse WJ (1985a) Anomeric dissociation between glucokinase activity and glycolysis in pancreatic islets. Biochem Int 11:77–84

    PubMed  CAS  Google Scholar 

  • Sener A, Leclercq-Meyer V, Marchand J, Giroix M-H, Dufrane SP, Malaisse WJ (1985b) Is glucokinase responsible for the anomeric specificity of glycolysis in pancreatic islets? J Biol Chem 260:12978–12981

    PubMed  CAS  Google Scholar 

  • Sener A, Malaisse-Lagae F, Xu LZ, Pilkis SJ, Malaisse WJ (1996) Anomeric specificity of the native and mutant forms of human β-cell glucokinase. Arch Biochem Biophys 328:26–34

    Article  PubMed  CAS  Google Scholar 

  • Tomita T, Kobayashi M (1976) Differential effects of α- and β-d-glucose on protection against alloxan toxicity in isolated islets. Biochem Biophys Res Commun 73:791–798, 22

    Article  PubMed  CAS  Google Scholar 

  • Valverde I, Barreto M, Malaisse WJ (1988) Stimulation by d-glucose of protein biosynthesis in tumoral insulin-producing cells (RINm5F line). Endocrinology 122:1443–1448

    Article  PubMed  CAS  Google Scholar 

  • Willem R, Biesemans M, Hallenga K, Lippens G, Malaisse-Lagae F, Malaisse WJ (1992) Dual anomeric specificity and dual anomerase activity of phosphoglucoisomerase quantified by two-dimensional phase sensitive 13C EXSY NMR. J Biol Chem 267:210–217

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Université Libre de Bruxelles, Brussels, Belgium

    Willy J. Malaisse

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  1. Willy J. Malaisse
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Correspondence to Willy J. Malaisse .

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  1. Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Malaisse, W.J. (2015). Physiology and Pathology of the Anomeric Specificity for the Glucose-Induced Secretory Response of Insulin-, Glucagon-, and Somatostatin-Producing Pancreatic Islet Cells. In: Islam, M. (eds) Islets of Langerhans. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6686-0_52

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