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Human Islet Autotransplantation

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Islets of Langerhans

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Abstract

Total pancreatectomy is a last option for patients in whom all other efforts for managing intractable pain caused by chronic pancreatitis have failed. When performed with a simultaneous islet autotransplantation, endogenous insulin production can be preserved to some extent. Although it does not necessarily prevent any future need for exogenous insulin, the diabetic state of the patient is less severe compared to pancreatectomy alone.

In contrast to islet allotransplantation, the patients do not require immunosuppressive drugs and are not at risk for autoimmune destruction or alloimmune rejection. Consequently, insulin independence is more likely to be preserved in autoislet-transplanted patients than in those patients who received alloislet transplants. Therefore, the setting of islet autotransplantation allows the study of the transplanted islets without interference from medication or immunological variables.

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Authors and Affiliations

  1. Department of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria

    Martin Hermann

  2. Daniel Swarovski Laboratory, Department of Visceral-, Transplant- and Thoracic Surgery, Center of Operative Medicine, Innsbruck Medical University, 6020, Innsbruck, Austria

    Raimund Margreiter & Paul Hengster

Authors
  1. Martin Hermann
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  2. Raimund Margreiter
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  3. Paul Hengster
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Correspondence to Martin Hermann .

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Editors and Affiliations

  1. Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Hermann, M., Margreiter, R., Hengster, P. (2015). Human Islet Autotransplantation. In: Islam, M. (eds) Islets of Langerhans. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6686-0_21

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