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Islets of Langerhans pp 767–784Cite as

β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)

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Abstract

This review summarizes key aspects of what has been learned about β-cell physiology from studies in ob/ob mice. Ob/ob mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia. Ob/ob mice have large pancreatic islets. The β-cells respond adequately to most stimuli, and ob/ob mice have been used as a rich source of pancreatic islets with high insulin release capacity. Depending on the genetic background, ob/ob mice can be described as a model for a constant prediabetic state or as a model for β-cell events leading to overt type 2 diabetes. The large capacity for islet growth and insulin release makes ob/ob mice from the C57Bl/6J or Umeå ob/ob strain a good model for studies on how β-cells can cope with prolonged functional stress.

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  1. Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umeå University, Umeå, Sweden

    Per Lindström

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  1. Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Lindström, P. (2015). β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice). In: Islam, M. (eds) Islets of Langerhans. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6686-0_15

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