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Handbook of Photonics for Biomedical Engineering pp 123–145Cite as

SPR Biosensors

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Abstract

Surface plasmon resonance (SPR) refers to excited charge density oscillations that exist along the boundary between a metal and a dielectric with permittivities of opposite signs. When the orientation of the electric field vector of an incident light matches the movement of free electrons in the metal as restricted by the boundary conditions associated with some material and structural parameters, surface plasma waves (SPW) can be excited, and consequently efficient coupling with large energy as guided electromagnetic wave along the interface may occur. This phenomenon of unexpected attenuation was first discovered by Wood [1] in 1902 when they measured the reflection of metallic gratings and found that some optical power was absorbed by the metal because of the excitation of SPW. The focus on developing SPR sensing was inspired after the introduction of attenuated total internal reflection (ATR) by Otto [2] and Kretschmann [3] in 1968. It was not until 1983 that Liedberg and Nylander [4] reported the first practical sensing application of SPR for biomolecular detection. Since then, SPR biosensors have experienced rapid development in the last two decades and become a valuable platform for qualitative and quantitative measurements of biomolecular interactions with the advantages of high sensitivity, versatile target molecule selection, and real-time detection. For this reason, SPR sensors are now widely adopted for meeting the needs of biology, food quality and safety analysis, and medical diagnostics.

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Acknowledgments

This work has been supported by the Hong Kong Research Grants Council under a group research project (Ref. # CUHK1/CRF/12G).

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Authors and Affiliations

  1. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong

    Aaron Ho-Pui Ho & Shu-Yuen Wu

  2. School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong

    Siu-Kai Kong

  3. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore

    Shuwen Zeng & Ken-Tye Yong

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  1. Aaron Ho-Pui Ho
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  2. Shu-Yuen Wu
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  3. Siu-Kai Kong
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  4. Shuwen Zeng
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  5. Ken-Tye Yong
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Correspondence to Aaron Ho-Pui Ho .

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Editors and Affiliations

  1. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong

    Aaron Ho-Pui Ho

  2. School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea (Republic of)

    Donghyun Kim

  3. Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

    Michael G. Somekh

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Ho, A.HP., Wu, SY., Kong, SK., Zeng, S., Yong, KT. (2017). SPR Biosensors. In: Ho, AP., Kim, D., Somekh, M. (eds) Handbook of Photonics for Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5052-4_38

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