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Handbook of the Cerebellum and Cerebellar Disorders pp 207–235Cite as

Specification and Development of GABAergic Interneurons

  • Reference work entry

Abstract

Of all cerebellar cells, the development of inhibitory interneurons is arguably least understood. The issue is further convoluted by the fact that knowledge of the diversity of this group of cells is rather limited. However, recent results allow to complement traditional morphological classifications with molecular and functional data that open a new perspective on cerebellar histogenesis and function. The early development of all cerebellar GABAergic interneurons is dependent on a single gene, Ptf1a. After leaving the ventricular neuroepithelium, precursors of these cells may be distinguished by their specific expression of the paired box gene, Pax2. These essentially postmitotic precursors are characterized by a so-far unique developmental plasticity. The terminal differentiation of cerebellar GABAergic interneurons is realized through an instructive mechanism thought to operate within the prospective white matter of the nascent cerebellum.

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Acknowledgments

I am indebted to the members of the laboratories of Ferdinado Rossi, John Oberdick, Torsten Pietsch, Stephan Baader, and my own lab for many inspiring and thought-provoking discussions. Any imperfections that remain are my responsibility entirely.

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Authors and Affiliations

  1. Anatomisches Institut – Anatomie und Zellbiologie, Rheinische Friedrich-Wilhelms-Universität, Nussallee 10, D-53115, Bonn, Germany

    Dr. Karl Schilling

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  1. Dr. Karl Schilling
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Correspondence to Karl Schilling .

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Editors and Affiliations

  1. Unité d'Etude du Mouvement (UEM), FNRS, Neurologie ULB Erasme, Bruxelles, Belgium

    Mario Manto

  2. Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  3. Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Orbassano, Turin, Italy

    Ferdinando Rossi

  4. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, California, CA, USA

    Donna L. Gruol

  5. Department of Integrative Physiolgy, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

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Schilling, K. (2013). Specification and Development of GABAergic Interneurons. In: Manto, M., Schmahmann, J.D., Rossi, F., Gruol, D.L., Koibuchi, N. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1333-8_11

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